Cloning and expression pattern of a mouse homologue of Drosophila sprouty in the mouse embryo
Cloning and expression pattern of a mouse homologue of Drosophila sprouty in the mouse embryo
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DOI：
10.1016/s0925-4773(98)00241-x
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发表时间：
1999-03-01
影响因子：
2.6
通讯作者：
Bellusci, S
中科院分区：
文献类型：
--
作者：
de Maximy, AA;Nakatake, Y;Bellusci, S
成纤维细胞生长因子(成纤维细胞生长因子)家族的信号分子在果蝇气管发育和小鼠肺发育过程中是指导芽生长所必需的。已经在果蝇中发现了一种潜在的成纤维细胞生长因子信号通路的抑制物，称为Sprouty，我们已经鉴定了Sprouty的三个潜在的小鼠同源物。其中一种叫做Sprouty4，表现出一种非常有限的表达模式。在8.0DPC(后天数)，Sprouty4在原始条纹区域有强烈的表达。在9.5和10.5dpc，Sprouty4在鼻胎盘、上颌突、耳囊、第二鳃弓、肢芽进展区和卵裂前中胚层表达。在体节的外侧区域也检测到Sprouty4的表达。在发育中的肺中，Sprouty4在远端间充质中广泛表达。(C)1999爱思唯尔爱尔兰科学有限公司。保留所有权利。
Signaling molecules belonging to the Fibroblast growth factor (Fgf) family are necessary for directing bud outgrowth during tracheal development in Drosophila and lung development in mouse. A potential inhibitor of the Fgf signaling pathway, called Sprouty, has been identified in Drosophila, We have identified three potential mouse homologues of sprouty. One of them, called Sprouty4, exhibits a very restricted expression pattern. At 8.0 dpc (days post coitum) Sprouty4 is strongly expressed in the primitive streak region. At 9.5 and 10.5 dpc, Sprouty4 is expressed in the nasal placode, the maxillary and mandibular processes, the otic vesicule, the second branchial arch, in the progress region of the limb buds and the presomitic mesoderm. Sprouty4 expression is also detected in the lateral region of the somites. In the developing lung, Sprouty4 is expressed broadly in the distal mesenchyme. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.