Coronary pressure-derived fractional flow reserve in the assessment of coronary artery stenoses
Coronary pressure-derived fractional flow reserve in the assessment of coronary artery stenoses
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DOI：
10.1007/s00330-012-2670-4
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发表时间：
2013-04-01
影响因子：
5.9
通讯作者：
Miller, Julie M.
中科院分区：
文献类型：
--
作者：
Kakouros, Nikolaos;Rybicki, Frank J.;Miller, Julie M.
基于导管的血管造影术是建立冠状动脉解剖结构的参考标准。虽然临床上常规使用，但管腔评估与缺血的生理测量相关性很差。此外，在选择性血管造影术之前，通常无法进行功能研究来识别和定位缺血。本文综述了血流储备分数（FFR）及其在指导具有潜在血流动力学显著性冠状动脉病变患者的患者管理中的作用，并讨论了FFR的理论、证据、适应症和局限性。此外，还包括目前正在评估与标准血流储备分数（FFR）相比准确性的新兴无创成像FFR替代品。冠状动脉压力衍生血流储备分数（FFR）可快速评估单个冠状动脉病变的血流动力学意义，并可在导管插入实验室中轻松进行。已证明使用FFR可有效指导冠状动脉血运重建术，从而改善患者结局。FFR是指导冠状动脉疾病治疗决策的宝贵模式。它是安全的，具有成本效益，并导致改善患者的结果。目前正在开发和评估用于评估CAD生理意义的无创成像模式。aEuro cent冠状动脉压力衍生血流储备分数（FFR）是血管造影术的重要辅助手段。aEuro cent FFR是指导冠状动脉疾病治疗决策的宝贵技术。aEuro cent FFR安全，成本效益高，并导致改善患者的结果。a欧元的新方向包括基于CT的非侵入性传统血流储备分数替代功能性病变的意义。
Catheter-based angiography is the reference-standard to establish coronary anatomy. While routinely employed clinically, lumen assessment correlates poorly with physiological measures of ischaemia. Moreover, functional studies to identify and localise ischaemia before elective angiography are often not available. This article reviews fractional flow reserve (FFR) and its role in guiding patient management for patients with a potentially haemodynamic significant coronary lesion.This review discusses the theory, evidence, indications, and limitations of FFR. Also included are emerging non-invasive imaging FFR surrogates currently under evaluation for accuracy with respect to standard FFR.Coronary pressure-derived fractional flow reserve (FFR) rapidly assesses the haemodynamic significance of individual coronary artery lesions and can readily be performed in the catheterisation laboratory. The use of FFR has been shown to effectively guide coronary revascularization procedures leading to improved patient outcomes.FFR is an invaluable modality in guiding coronary disease treatment decisions. It is safe, cost-effective and leads to improved patient outcomes. Non-invasive imaging modalities to assess the physiologic significance of CAD are currently being developed and evaluated.aEuro cent Coronary pressure-derived fractional flow reserve (FFR) is an important adjunct to angiography.aEuro cent FFR is an invaluable technique in guiding coronary disease treatment decisions.aEuro cent FFR is safe, cost-effective and leads to improved patient outcomes.aEuro cent New directions include CT-based non-invasive conventional FFR surrogates for functional lesion significance.