Seborrheic keratoses: appearance in course of exfoliative erythroderma and regression associated with histologic mononuclear cell inflammation.
Seborrheic keratoses: appearance in course of exfoliative erythroderma and regression associated with histologic mononuclear cell inflammation.
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脂溢性角化病：剥脱性红皮病病程中的出现和与组织学单核细胞炎症相关的消退。
DOI：
10.1001/archderm.118.8.615
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发表时间：
1982
影响因子：
--
通讯作者：
R. Winkelmann
中科院分区：
文献类型：
--
作者：
A. Berman;R. Winkelmann
我们观察到一个病人，其中大量的脂溢性角化病发展过程中的全身性皮炎进展为剥脱性红皮病。最后发现一个肾脏肿块，并进行了手术切除。在显微镜检查，肾脏肿瘤被证明是一个良性纤维壁，多房囊肿。肾囊肿切除后，红皮病和剥脱消退。几个月后，注意到脂溢性角化病变得更小、更平、数量更少。显微镜检查五个这样的退化病变显示，在每一个情况下，单核细胞浸润的脂溢性角化病。我们的研究结果证实了早期的报道，即在广泛的炎症性皮肤病过程中发生的脂溢性角化病样病变在皮肤病控制后可能会消退，并表明单核细胞炎症可能是这些病变消退的机制。
We observed a patient in whom large numbers of seborrheic keratoses developed in the course of a generalized dermatitis that progressed into an exfoliative erythroderma. A renal mass was finally discovered and was surgically excised. On microscopic examination, the kidney tumor proved to be a benign fibrous-walled, multilocular cyst. After removal of the renal cyst, the erythroderma and exfoliation subsided. A few months later, the seborrheic keratoses were noted to have become smaller, flatter, and fewer in number. Microscopic examination of five such involuting lesions showed, in each instance, mononuclear cell infiltration of the seborrheic keratoses. Our findings confirm earlier reports that seborrheic keratosis-like lesions developing during the course of widespread inflammatory cutaneous disorders may regress after control of the dermatosis and suggest that mononuclear cell inflammation may be the mechanism by which regression of these lesions is accomplished.