Neurodevelopmental Outcomes of Very Low Birth Weight Infants at 18-24 Months, Corrected Gestational Age in a Tertiary Health Centre: A Prospective Cohort Study
Neurodevelopmental Outcomes of Very Low Birth Weight Infants at 18-24 Months, Corrected Gestational Age in a Tertiary Health Centre: A Prospective Cohort Study
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DOI：
10.1093/tropej/fmz006
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发表时间：
2019-12-01
影响因子：
2
通讯作者：
Yadav, Bijesh
中科院分区：
文献类型：
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作者：
Oommen, Samuel P.;Santhanam, Sridhar;Yadav, Bijesh
目的：为了确定一组极低出生体重（VLBW）婴儿神经发育不良结局的患病率和危险因素，研究对象和方法：对来自印度南部一家教学医院的643名VLBW幸存者中的422名婴儿进行随访，以评估他们的神经发育结局。在完成评估的422名儿童中，分析了359名儿童的评估结果，这些儿童的评估是在18至24个月之间完成的。37名儿童（10.31%）的神经发育结果较差，6名儿童（1.67%）患有脑瘫，1名儿童患有视力障碍，另1名儿童患有听力障碍。在多变量分析中，出生后生长不良与神经发育不良结局独立相关（p = 0.045）。新生儿并发症与发育outcome.Conclusion：尽管新生儿并发症的发生率较低，与西方队列相比，显着比例的VLBW婴儿神经发育不良的结果。出生后生长不良是发育结果的重要决定因素
Objective: To determine the prevalence and risk factors for poor neurodevelopmental outcome in a cohort of very low birth weight (VLBW) infants.Subjects and methods: Four hundred and twenty-two infants of a total of 643 VLBW survivors from a teaching hospital in South India were followed up to assess their neurodevelopmental outcomes.Results: Among the 422 children who completed the assessment, results of 359 children whose assessments were done between 18 and 24 months were analysed. Thirty-seven children (10.31%) had poor neurodevelopmental outcome, six children [1.67%] had cerebral palsy, one child had visual impairment and another had hearing impairment. Poor post-natal growth was independently associated with poor neurodevelopmental outcomes in the multivariate analysis (p = 0.045). Neonatal complications were not associated with the developmental outcome.Conclusion: Despite lower rates of neonatal complications compared with Western cohorts, significant proportion of VLBW infants had poor neurodevelopmental outcomes. Poor post-natal growth was an important determinant of the developmental outcome