Modeling longitudinal change in motor and cognitive processing speed in presymptomatic Huntington's disease
Modeling longitudinal change in motor and cognitive processing speed in presymptomatic Huntington's disease
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DOI：
10.1080/13803395.2011.574606
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发表时间：
2011-01-01
影响因子：
2.2
通讯作者：
Brandt, Jason
中科院分区：
文献类型：
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作者：
Maroof, David Aaron;Gross, Alden L.;Brandt, Jason
具有导致亨廷顿病（HD）的基因突变的人在表现HD前几年表现出较低的认知测试分数。大多数研究通过使用基于已发表算法的估计时间来表现HD来检查症状前人群的认知表现。我们使用客观标准（即，定量神经学检查评分
Persons who have the genetic mutation responsible for Huntington's disease (HD) have been shown to exhibit lower cognitive test scores years prior to manifest HD. Most studies have examined cognitive performance in presymptomatic persons by using estimated times to manifest HD based on published algorithms. We followed 19 gene-positive persons who were presymptomatic using an objective criterion (i.e., Quantified Neurological Exam score