Comparison of a high saturated fat diet with a high carbohydrate diet during pregnancy and lactation: effects on insulin sensitivity in offspring of rats
Comparison of a high saturated fat diet with a high carbohydrate diet during pregnancy and lactation: effects on insulin sensitivity in offspring of rats
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DOI：
10.1016/j.metabol.2005.04.020
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发表时间：
2005-10-01
影响因子：
9.8
通讯作者：
Hermansen, K
中科院分区：
文献类型：
--
作者：
Gregersen, S;Dyrskog, SEU;Hermansen, K
胰岛素抵抗在代谢综合征中起着关键作用，并受膳食脂肪的数量和饱和度的影响。产前营养过剩和营养不足都会导致胰岛素抵抗。这项研究的目的是探索母亲在怀孕期间摄入的膳食脂肪对后代胰岛素敏感性的影响。雌性Wistar大鼠孕期饲喂高碳水化合物(CHO)或饱和脂肪(SAFA)饲料。雄性子代分为5个亚组：第1组(对照组)和第3组分别在出生后继续服用CHO或SAFA。母亲服用CHO的第2组在哺乳期间继续服用CHO饮食，并在断奶后改为SAFA。母亲服用SAFA的第4组在断奶期间继续服用SAFA，并在断奶后改为CHO。对于第5组，喂饲SAFA饲料的母亲的后代在出生后立即改为喂饲CHO饲料的母亲，并在断奶后继续喂同样的饲料。在16周龄时，进行正常血糖高胰岛素钳夹。SAFA饮食组大鼠葡萄糖输注率降低(第2组24.7+/-2.0 mg/kg/min；第3组22.0+/-1.9 mg/kg/min；P
Insulin resistance plays a critical role in metabolic syndrome and is influenced by the amount and saturation of dietary fat. Both prenatal over and under nutrition can program susceptibility to insulin resistance. The aim of the study was to explore the impact of dietary fat given to mothers during gestation on the insulin sensitivity of the offspring. Female Wistar rats were fed with diets rich in carbohydrate (CHO) or saturated fat (SAFA) during pregnancy. The male offspring was split into 5 subgroups: groups 1 (control) and 3 continued on CHO or SAFA after birth, respectively. Group 2 with mothers on CHO continued on the CHO diet during the nursing period and changed to SAFA postweaning. Group 4 with mothers on SAFA continued on SAFA during the weaning period and changed to CHO postweaning. For group 5 the offspring of mothers given SAFA diet was changed to nursing mothers on CHO diet immediately after birth and continued on the same diet postweaning. At the age of 16 weeks, a euglycemic hyperinsulinemic clamp was performed. The glucose infusion rate was lowered in the groups receiving the SAFA diet (group 2, 24.7 +/- 2.0 mg/kg per minute; group 3, 22.0 +/- 1.9 mg/kg per minute; P