The Biomarkers of Exposure and Effect in Agriculture (BEEA) Study: Rationale, Design, Methods, and Participant Characteristics.
The Biomarkers of Exposure and Effect in Agriculture (BEEA) Study: Rationale, Design, Methods, and Participant Characteristics.
复制标题
DOI：
10.1080/15287394.2015.1091414
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Alavanja MC
中科院分区：
文献类型：
--
作者：
Hofmann JN;Beane Freeman LE;Lynch CF;Andreotti G;Thomas KW;Sandler DP;Savage SA;Alavanja MC
农业暴露，包括农药，内毒素和过敏原与各种癌症和其他慢性疾病的风险有关，尽管这些关联背后的生物学机制通常尚不清楚。为了促进未来的分子流行病学调查，2010年在农业健康研究中启动了农业暴露和影响生物标志物（BEEA）研究，这是爱荷华州和北卡罗来纳州的一个大型前瞻性队列。在这里，BEEA的设计和方法进行了说明，并初步频率的参与者的特点和目前的农业风险报告。至少有1,600名50岁以上的男性农民将参加BEEA研究。在家庭访问期间，参与者被要求完成关于最近农业暴露的详细访谈，并提供血液，尿液和（自2013年以来）房屋灰尘的样本。截至2014年9月中旬，共有1，233名参与者注册。这些参与者中的大多数（83%）在接受采访时仍在务农。在仍在耕作的人中，最常报告的作物是玉米（81%）和大豆（74%），最常报告的动物是肉牛（35%）和猪（13%）。有861名（70%）参与者在访谈前12个月报告了职业农药使用情况;在这些参与者中，最常见的除草剂是草甘膦（83%）和2，4-D（72%），最常见的杀虫剂是马拉硫磷（21%），氟氯氰菊酯（13%）和氯菊酯（12%）。BEEA内的分子流行病学调查有可能对这些或其他农业暴露影响疾病风险的生物机制产生重要的新见解。
Agricultural exposures including pesticides, endotoxin, and allergens have been associated with risk of various cancers and other chronic diseases, although the biological mechanisms underlying these associations are generally unclear. To facilitate future molecular epidemiologic investigations, in 2010 the study of Biomarkers of Exposure and Effect in Agriculture (BEEA) was initiated within the Agricultural Health Study, a large prospective cohort in Iowa and North Carolina. Here the design and methodology of BEEA are described and preliminary frequencies for participant characteristics and current agricultural exposures reported. At least 1,600 male farmers over 50 years of age will be enrolled in the BEEA study. During a home visit, participants are asked to complete a detailed interview about recent agricultural exposures and provide samples of blood, urine, and (since 2013) house dust. As of mid-September 2014, a total of 1,233 participants have enrolled. Most of these participants (83%) were still farming at the time of interview. Among those still farming, the most commonly reported crops were corn (81%) and soybeans (74%) and the most frequently noted animals were beef cattle (35%) and hogs (13%). There were 861 (70%) participants who reported occupational pesticide use in the 12 months prior to interview; among these participants, the most frequently noted herbicides were glyphosate (83%) and 2,4-D (72%), and most commonly reported insecticides were malathion (21%), cyfluthrin (13%), and permethrin (12%). Molecular epidemiologic investigations within BEEA have the potential to yield important new insights into the biological mechanisms through which these or other agricultural exposures influence disease risk.