Comparison of exhaled nitric oxide measurements between NIOX MINO® electrochemical and Ecomedics chemiluminescence analyzer
Comparison of exhaled nitric oxide measurements between NIOX MINO® electrochemical and Ecomedics chemiluminescence analyzer
复制标题
DOI：
10.1016/j.rmed.2008.06.021
复制
发表时间：
2008-11-01
影响因子：
4.3
通讯作者：
Diamant, Z.
中科院分区：
文献类型：
--
作者：
Boot, J. D.;de Ridder, L.;Diamant, Z.
背景：呼出气一氧化氮（eNO）是（特应性）哮喘活动性气道炎症的一种已确立的非侵入性生物标志物。抗炎治疗，如吸入皮质类固醇，有效地降低eNO水平。NIOX MINO（R）（MINO）是一种手持式、相对便宜的电化学装置，已被证明可产生与NIOX固定式装置相当的eNO测量结果。目的：将MINO的测量结果与另一种广泛使用并经过验证的固定式化学发光分析仪Ecomedics（ECO）进行比较。方法：我们在50名受试者（19名健康志愿者，18名健康吸烟者和13名不吸烟的特应性哮喘患者，未接受控制器治疗）中进行了随后的ECO和MINO eNO测量，两次访问间隔4-10天。ECO的三个可接受的测量和第一个可接受的测量与MINO的平均值被用于analysis.Results：这两种设备都产生了可重复的eNO值为所有受试者的两次访问，与22.7%（ECO）和18.3%（MINO）的总体CV。两种器械之间存在显著相关性（r = 0.97，p < 0.0001）。Bland-Altman图显示了整个研究人群和三个个体亚组的高度一致性（MINO与ECO的平均差异= -10%; 95%一致性限度为-36%和+28%. Conclusions：MINO测量的呼出NO值具有重现性，并与ECO一致。我们的研究结果进一步证明了MINO的可靠性，并保证其在研究和临床实践中的适用性。(C)2008爱思唯尔有限公司保留所有权利。
Background: Exhaled nitric oxide (eNO) is an established, noninvasive biomarker of active airway inflammation in (atopic) asthma. Treatment with anti-inflammatory therapy, such as inhaled corticosteroids, effectively decreases eNO levels. The NIOX MINO (R) (MINO) is a hand-held, relatively inexpensive, electrochemical device that has been shown to yield comparable eNO measurements to the NIOX stationary unit.Aim: To compare measurements of MINO with another widely used and validated stationary chemiluminescence analyzer, the Ecomedics (ECO).Methods: We performed subsequent eNO measurements on ECO and MINO in 50 subjects (19 healthy volunteers, 18 healthy smokers and 13 non-smoking, atopic asthmatics, not on controller therapy) on two visits 4-10 days apart. The mean of three acceptable measurements by ECO and the first acceptable measurement with the MINO were used for analysis.Results: Both devices yielded reproducible eNO values for all subjects on both visits, with an overall CV of 22.7% (ECO) and 18.3% (MINO). A significant correlation was found between both devices (r = 0.97, p < 0.0001). Bland-Altman plots showed a high degree of agreement for the entire study population (mean difference MINO vs ECO = -10%; 95% limit of agreement were -36% and +28%) and in the three individual subgroups.Conclusions: Exhaled NO values measured with the MINO are reproducible and in agreement with the ECO. Our results add further evidence to the reliability of the MINO and warrant its applicability in research and clinical practice. (C) 2008 Elsevier Ltd. All rights reserved.