Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex
Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex
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DOI：
10.1074/jbc.m212112200
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发表时间：
2003-03-28
影响因子：
4.8
通讯作者：
Li, XX
中科院分区：
文献类型：
--
作者：
Jiang, ZF;Johnson, HJ;Li, XX
哺乳动物白细胞介素-1受体（IL-1 R）/Toll样受体（TLR）下游的信号传导途径与果蝇Toll蛋白介导的信号传导途径在进化上是保守的。Toll通过衔接分子Tube和丝氨酸-苏氨酸激酶Pelle启动其信号。Pelle与哺乳动物中的IL-1 R相关激酶（IRAK）家族成员高度同源。最近，在果蝇中发现了一种名为Pellino的新型Pelle相互作用蛋白。我们现在报告一个哺乳动物对应的Pellino，称为Pellino 1，这是所需的NF κ B激活和IL-8基因表达的IL-1，可能通过其信号依赖性的相互作用与IRAK 4，IRAK，和肿瘤坏死因子受体相关因子6（TRAF 6）。Pellino 1-IRAK-IRAK 4-TRAF 6信号传导复合物可能是中间体，位于IL-1途径中IL-1受体复合物和TAK 1复合物之间。
The signaling pathway downstream of the mammalian interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) is evolutionally conserved with that mediated by the Drosophila Toll protein. Toll initiates its signal through the adapter molecule Tube and the serine-threonine kinase Pelle. Pelle is highly homologous to members of the IL-1R-associated kinase (IRAK) family in mammals. Recently, a novel Pelle-interacting protein called Pellino was identified in Drosophila. We now report a mammalian counterpart of Pellino, termed Pellino 1, which is required for NFkappaB activation and IL-8 gene expression in response to IL-1, probably through its signal-dependent interaction with IRAK4, IRAK, and the tumor necrosis factor receptor-associated factor 6 (TRAF6). The Pellino 1-IRAK-IRAK4-TRAF6 signaling complex is likely to be intermediate, located between the IL-1 receptor complex and the TAK1 complex in the IL-1 pathway.