Suppression of atopic dermatitis in mice model by reducing inflammation utilizing phosphatidylserine-coated biodegradable microparticles
Suppression of atopic dermatitis in mice model by reducing inflammation utilizing phosphatidylserine-coated biodegradable microparticles
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DOI：
10.1080/09205063.2015.1100844
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发表时间：
2015-10
期刊：
影响因子：
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通讯作者：
Purnima Kumar;Md. Zahangir Hosain;Jeong-Hun Kang;Masafumi Takeo;A. Kishimura;Takeshi Mori;Y. Katayama
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文献类型：
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作者：
Purnima Kumar;Md. Zahangir Hosain;Jeong-Hun Kang;Masafumi Takeo;A. Kishimura;Takeshi Mori;Y. Katayama
控制炎症反应对于避免包括特应性皮炎（AD）在内的许多疾病中的慢性炎症是重要的。在这项研究中，我们尝试在AD小鼠模型中使用磷脂酰丝氨酸（PS）包被的微粒，以实现巨噬细胞表型到抗炎状态的调节。在这里，我们制备了聚（D，L-乳酸）微粒的外壳上涂覆PS。我们证实了PS包被的微粒的细胞摄取，这导致炎性细胞因子产生的显著下调。在AD的小鼠模型中，皮下注射PS包被的微粒12天。与用PC包被的微粒处理的小鼠相比，小鼠显示出AD症状的发展显著减少。
Controlling inflammatory response is important to avoid chronic inflammation in many diseases including atopic dermatitis (AD). In this research, we tried using a phosphatidylserine (PS)-coated microparticles in the AD mouse model for achieving the modulation of the macrophage phenotype to an anti-inflammatory state. Here, we prepared poly (D,L-lactic acid) microparticle coated with PS on the outside shell. We confirmed the cellular uptake of the PS-coated microparticle, which leads to the significant downregulation of the inflammatory cytokine production. In the mouse model of AD, the PS-coated microparticle was injected subcutaneously for a period of 12 days. The mice showed significant reduction in the development of AD symptoms comparing with the mice treated with the PC-coated microparticle.