INHIBITION OF AN IN-VIVO ANTIGEN-SPECIFIC IGE RESPONSE BY ANTIBODIES TO CD23
INHIBITION OF AN IN-VIVO ANTIGEN-SPECIFIC IGE RESPONSE BY ANTIBODIES TO CD23
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DOI：
10.1126/science.8351517
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发表时间：
1993-08-20
期刊：
影响因子：
56.9
通讯作者：
BONNEFOY, JY
中科院分区：
文献类型：
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作者：
FLORESROMO, L;SHIELDS, J;BONNEFOY, JY
免疫球蛋白E（IgE）介导许多过敏反应。CD23是一种45千道尔顿的II型跨膜糖蛋白，在许多细胞类型中表达。它是一种低亲和力IgE受体，与CD 21特异性相互作用，从而在体外调节B淋巴细胞的IgE产生。在过敏原特异性IgE反应的体内模型中，给予重组人截短CD23的兔多克隆抗体导致对卵清蛋白特异性IgE合成的抑制高达90%。Fab和完整IgG在体外和体内均抑制IgE产生。因此，CD23参与体内IgE合成的调节，因此在过敏性疾病中可能是重要的。
Immunoglobulin E (IgE) mediates many allergic responses. CD23 is a 45-kilodalton type II transmembrane glycoprotein expressed in many cell types. It is a low-affinity IgE receptor and interacts specifically with CD21, thereby modulating IgE production by B lymphocytes in vitro. In an in vivo model of an allergen-specific IgE response, administration of a rabbit polyclonal antibody to recombinant human truncated CD23 resulted in up to 90 percent inhibition of ovalbumin-specific IgE synthesis. Both Fabs and intact IgG inhibited IgE production in vitro and in vivo. Thus, CD23 participates in the regulation of IgE synthesis in vivo and so could be important in allergic disease.