The dependence of relaxation rates and chemical shift on the size of the imaged molecules and the concentration of MRI contrast agents
The dependence of relaxation rates and chemical shift on the size of the imaged molecules and the concentration of MRI contrast agents
复制标题
弛豫率和化学位移对成像分子大小和 MRI 造影剂浓度的依赖性
DOI：
10.1080/00268970903250547
复制
发表时间：
2009-01-01
影响因子：
1.7
通讯作者：
Lai, Ping-Hong
中科院分区：
文献类型：
--
作者：
Ding, Shangwu;Wu, Zhen;Lai, Ping-Hong
研究了两种典型的钆类磁共振造影剂的弛豫速率和化学位移的增强现象。弛豫增强或化学位移变化取决于成像核素所在的分子的大小：小分子显示浓度与弛豫增强或化学位移变化之间的完美线性关系，而对于大分子，观察到明显的非线性。该现象也证实了与大分子样品的真实的图像。提出了一个定量的理论解释的现象，这一现象的意义，MRI的材料和生物系统进行了讨论。
An intriguing phenomenon on enhancement of the relaxation rates and chemical shift of two typical magnetic resonance imaging (MRI) contrast agents based on gadolinium complex is observed. The relaxation enhancement or chemical shift change depends on the size of the molecule where the imaged nuclear species is located: the small molecules show a perfect linear relationship between the concentration and the relaxation enhancement or chemical shift change while for macromolecules pronounced nonlinearity is observed. The phenomenon is also confirmed with real images of a macromolecular sample. A quantitative theoretical interpretation of the phenomenon is proposed and the significance of this phenomenon to MRI of materials and biological systems is discussed.