31P magnetic resonance spectroscopy to measure in vivo cardiac energetics in normal myocardium and hypertrophic cardiomyopathy: Experiences at 3T
31P magnetic resonance spectroscopy to measure in vivo cardiac energetics in normal myocardium and hypertrophic cardiomyopathy: Experiences at 3T
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DOI：
10.1016/j.ejrad.2008.10.018
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发表时间：
2010-02-01
影响因子：
3.3
通讯作者：
Frenneaux, Michael
中科院分区：
文献类型：
--
作者：
Shivu, Ganesh Nallur;Abozguia, Khalid;Frenneaux, Michael
背景：P-31 磁共振波谱 (MRS) 可以测量心肌中的体内高能磷酸盐动力学。虽然传统上 P-31 心脏频谱在 1.5T 下执行，但更高场强的心脏 MRS 理论上可以提高信噪比 (SNR) 和频谱分辨率，从而提高心脏频谱的灵敏度和特异性。本研究介绍了在健康志愿者和肥厚型心肌病患者中进行 3T 心脏波谱分析的可重复性和可行性。方法：使用 Phillips 3T Achieva 扫描仪对 37 名健康志愿者和 26 名肥厚型心肌病 (HCM) 患者进行心脏波谱分析，以测试该方案的可行性。为了测试重复性，对一名志愿者在不同的场合进行了八次扫描。使用图像选择体内光谱 (ISIS) 体积定位进行单体素 P-31 MRS。结果：对一个人进行的八次测量的平均磷酸肌酸/三磷酸腺苷 (PCr/ATP) 比率为 2.11 +/- 0.25。 Bland Altman 图显示 PCr/ATP 比率测量结果存在 12% 的方差。与对照组相比，HCM 患者的 PCr/ATP 比率显着降低，分别为 1.42 +/- 0.51 和 2.11 +/- 0.57，P < 0.0001。 （所有结果均以平均标准差表示）。结论：在此，我们证明 3T 心脏 P-31 MRS 是测量心肌体内高能磷酸盐动力学的可靠方法，用于临床研究和诊断。根据我们的数据，肥厚型心肌病患者的心脏能量状态受损是无可争议的。 (C) 2008 Elsevier Ireland Ltd. 保留所有权利。
Background: P-31 magnetic resonance spectroscopy (MRS) allows measurement of in vivo high-energy phosphate kinetics in the myocardium. While traditionally P-31 cardiac spectroscopy is performed at 1.5T, cardiac MRS at higher field strength can theoretically increase signal to noise ratio (SNR) and spectral resolution therefore improving sensitivity and specificity of the cardiac spectra. The reproducibility and feasibility of performing cardiac spectroscopy at 3T is presented here in this study in healthy volunteers and patients with hypertrophic cardiomyopathy.Methods: Cardiac spectroscopy was performed using a Phillips 3T Achieva scanner in 37 healthy volunteers and 26 patients with hypertrophic cardiomyopathy (HCM) to test the feasibility of the protocol. To test the reproducibility a single volunteer was scanned eight times on separate occasions. A single voxel P-31 MRS was performed using Image Selected In vivo Spectroscopy (ISIS) volume localization.Results: The mean phosphocreatine/adenosine triphosphate (PCr/ATP) ratio of the eight measurements performed on one individual was 2.11 +/- 0.25. Bland Altman plots showed a variance of 12% in the measurement of PCr/ATP ratios. The PCr/ATP ratio was significantly reduced in HCM patients compared to controls, 1.42 +/- 0.51 and 2.11 +/- 0.57, respectively, P < 0.0001. (All results are expressed as mean standard deviation).Conclusions: Here we demonstrate that cardiac P-31 MRS at 3T is a reliable method of measuring in vivo high-energy phosphate kinetics in the myocardium for clinical studies and diagnostics. Based on our data an impairment of cardiac energetic state in patients with hypertrophic cardiomyopathy is indisputable. (C) 2008 Elsevier Ireland Ltd. All rights reserved.