Anxiolytic effect of music exposure on BDNFMet/Met transgenic mice
Anxiolytic effect of music exposure on BDNFMet/Met transgenic mice
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音乐暴露对 BDNFMet/Met 转基因小鼠的抗焦虑作用
DOI：
10.1016/j.brainres.2010.05.080
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发表时间：
2010-08-06
期刊：
影响因子：
2.9
通讯作者：
Chen, Zhe-Yu
中科院分区：
文献类型：
--
作者：
Li, Wen-Jing;Yu, Hui;Chen, Zhe-Yu
脑源性神经营养因子（BDNF）已被报道在焦虑、情绪稳定剂和情感障碍的病理生理调节中发挥重要作用。最近，已发现BDNF基因（Val 66 Met）中的单核苷酸多态性（SNP）与抑郁症和焦虑症相关。人源化BDNFMet/Met基因敲入转基因小鼠表现出增加的焦虑相关行为，这些行为对5-羟色胺再摄取抑制剂氟西汀无反应。众所周知，音乐能够引起情绪变化，包括抗焦虑作用。在本研究中，我们发现，音乐治疗可以显着降低焦虑状态的BDNF Met/Met小鼠，但在BDNF+/-，小鼠相比，白色噪声暴露在开放领域和高架十字迷宫测试。此外，与白色噪声暴露相比，在暴露于音乐的成年BDNF Met/Met小鼠中，前额叶皮层（PFC）、杏仁核和海马中BDNF表达水平显著增加。然而，音乐治疗不能上调BDNF+/-小鼠PFC、杏仁核和海马中的BDNF水平，这表明BDNF在音乐的抗焦虑作用中起重要作用。总之，我们的结果意味着音乐可以为具有这种遗传性BDNFMet变体的人类焦虑症提供有效的治疗干预。(C)2010爱思唯尔有限公司版权所有。
Brain-derived neurotrophic factor (BDNF) has been reported to play important roles in the modulation of anxiety, mood stabilizers, and pathophysiology of affective disorders. Recently, a single nucleotide polymorphism (SNP) in the BDNF gene (Val66Met) has been found to be associated with depression and anxiety disorders. The humanized BDNFMet/Met knock-in transgenic mice exhibited increased anxiety-related behaviors that were unresponsive to serotonin reuptake inhibitors, fiuoxetine. Music is known to be able to elicit emotional changes, including anxiolytic effects. In this study, we found that music treatment could significantly decrease anxiety state in BDNFMet/Met mice, but not in BDNF+/-, mice compared with white noise exposure in open field and elevated plus maze test. Moreover, in contrast to white noise exposure, BDNF expression levels in the prefrontal cortex (PFC), amygdala and hippocampus were significantly increased in music-exposed adult BDNFMet/Met mice. However, music treatment could not upregulate BDNF levels in the PFC, amygdala, and hippocampus in BDNF+/- mice, which suggests the essential role of BDNF in the anxiolytic effect of music. Together, our results imply that music may provide an effective therapeutic intervention for anxiety disorders in humans with this genetic BDNFMet variant. (C) 2010 Elsevier B.V. All rights reserved.