Frontal P3 event-related potential is related to brain glutamine/glutamate ratio measured in vivo
Frontal P3 event-related potential is related to brain glutamine/glutamate ratio measured in vivo
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DOI：
10.1016/j.neuroimage.2015.02.014
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发表时间：
2015-05-01
期刊：
影响因子：
5.7
通讯作者：
Oenguer, Dost
中科院分区：
文献类型：
--
作者：
Hall, Mei-Hua;Jensen, J. Eric;Oenguer, Dost
背景：听觉P3事件相关电位（ERP）被认为是与注意和工作记忆过程相关的认知加工的指标。药物激发研究表明，谷氨酸神经传递在调节P3 ERP中起着重要作用。然而，虽然谷氨酸活性与人类P3 ERP反应之间的直接联系被怀疑，但机制细节仍在很大程度上未知。我们在这里调查的P3 ERP和指标之间的关系，在体内测量的质子磁共振波谱（H-1 MRS）。我们假设，一个较高的指数，前扣带回（ACC）和顶叶枕叶（POC）皮质的谷氨酸能处理（谷氨酰胺/谷氨酸的比例，缩写为谷氨酰胺/谷氨酸）将与较大的额叶P3a和顶叶P3b振幅，分别。方法：额叶P3a（FZ）和顶叶P3b（PZ）收集了32名健康参与者谁进行了听觉oddball任务。在4T MR扫描仪上使用J-分辨MR波谱测量静息谷氨酸（Glu）、谷氨酰胺（Gln）和Gln/Glu（谷氨酸能加工的指标）。结果：额叶P3a波幅与ACC Gln/Glu比值（偏相关R = 0.57; P = 0.001）、与ACC Gln浓度（偏相关R = 0.43; P = 0.02）呈显著正相关。顶叶P3b和谷氨酸指数在POC之间的关系不显着。结论：这些结果表明，在ACC和额叶P3 ERP的谷氨酸神经递质功能的指数之间的特定连接，提供了一个新的洞察头皮记录EEG响应的神经化学。在精神分裂症和其他精神疾病中已经观察到谷氨酸神经传递的缺失，并且可能是疾病相关的P3 ERP缺陷的基础。(C)2015 Elsevier Inc. All rights reserved.
Background: The auditory P3 event-related potential (ERP) is thought to index cognitive processing relevant to attention and working memory processes. Drug challenge studies suggest that glutamate neurotransmission plays an important role in modulating P3 ERP. However, while direct links between glutamate activity and P3 ERP response in humans are suspected, mechanistic details remain largely unknown. We investigated here the relationships between P3 ERP and indices of glutamatergic processing measured in vivo with proton magnetic resonance spectroscopy (H-1 MRS). We hypothesized that a higher index of glutamatergic processing (glutamine/glutamate ratio; abbreviated Gln/Glu) in the anterior cingulate (ACC) and in the parietal-occipital (POC) cortices would associate with larger frontal P3a and parietal P3b amplitudes, respectively.Methods: Frontal P3a (Fz) and parietal P3b (Pz) were collected from 32 healthy participants who performed an auditory oddball task. Resting glutamate (Glu), glutamine (Gln), and Gln/Glu (an index of glutamatergic processing) measures were obtained on a 4 T MR scanner using J-resolved MR spectroscopy. Linear regression and partial correlations were used for statistical analysis.Results: Significant positive correlations were found between frontal P3a amplitude and ACC Gln/Glu ratio (partial R = 0.57; P = 0.001) and between frontal P3a amplitude and ACC Gln concentration (partial R = 0.43; P = 0.02). Relationships between parietal P3b and the glutamate indices in the POC were not significant.Conclusions: These results indicate a specific connection between an index of glutamate neurotransmitter function in ACC and frontal P3 ERP, providing a novel insight into the neurochemistry underlying scalp recorded EEG response. Abnormalities in glutamate neurotransmission have been observed in schizophrenia and other psychiatric conditions and may underlie illness related deficits of P3 ERP. (C) 2015 Elsevier Inc. All rights reserved.