Micro-kelvin temperature-stable system for biocalorimetry applications.
Micro-kelvin temperature-stable system for biocalorimetry applications.
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DOI：
10.1063/5.0188285
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发表时间：
2024-03
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影响因子：
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通讯作者：
Kanishka Panda;Rohith Mittapally;Pramod Reddy;Swathi Yadlapalli;E. Meyhofer
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作者：
Kanishka Panda;Rohith Mittapally;Pramod Reddy;Swathi Yadlapalli;E. Meyhofer
实现微开尔文(µK)温度稳定性对于许多量热应用至关重要。例如，亚纳瓦级的生物热量计需要将量热计的温度稳定在微K水平。在这里，我们将介绍如何在由两个嵌套屏蔽件和一个悬挂毛细管组成的原型量热系统中实现µK温度稳定性，该系统非常适合于生物量热应用。具体地说，我们的研究表明，通过在屏蔽层之间采用微托真空水平的嵌套式屏蔽层，以及对屏蔽层温度的精确反馈控制(使用高分辨率温度传感器执行)，环境温度波动对内层屏蔽层和毛细管的影响可以减弱100dB的∼。我们还表明，对于内屏传感器和毛细管传感器，这种衰减是实现±1和±3µK(振荡幅度)温度稳定性的关键，在室温(∼20.9±0.2°C)下以1 MHz的带宽测量。我们期望这里描述的方法将在推进生物量热学方面发挥关键作用。
Achieving micro-kelvin (µK) temperature stability is critical for many calorimetric applications. For example, sub-nanowatt resolution biocalorimetry requires stabilization of the temperature of the calorimeter to µK levels. Here, we describe how µK temperature stability can be accomplished in a prototypical calorimetric system consisting of two nested shields and a suspended capillary tube, which is well suited for biocalorimetry applications. Specifically, we show that by employing nested shields with µTorr-levels of vacuum in the space between them as well as precise feedback control of the temperature of the shields (performed using high-resolution temperature sensors), the effect of ambient temperature fluctuations on the inner shield and the capillary tube can be attenuated by ∼100 dB. We also show that this attenuation is key to achieving temperature stabilities within ±1 and ±3 µK (amplitude of oscillations) for the inner shield and the capillary tube sensor, respectively, measured in a bandwidth of 1 mHz over a period of 10 h at room temperature (∼20.9 ± 0.2 °C). We expect that the methods described here will play a key role in advancing biocalorimetry.