Analyzing Opposing Interactions Between Sphingosine 1-Phosphate Lyase and Influenza A Virus.
Analyzing Opposing Interactions Between Sphingosine 1-Phosphate Lyase and Influenza A Virus.
复制标题
分析 1-磷酸鞘氨醇裂解酶和甲型流感病毒之间的相反相互作用。
DOI：
10.1089/dna.2022.0071
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发表时间：
2022
影响因子：
3.1
通讯作者：
Hahm,Bumsuk
中科院分区：
文献类型：
--
作者：
Wolf,JenniferJ;Saba,JulieD;Hahm,Bumsuk
鞘氨醇1-磷酸裂解酶(SPL)是鞘氨醇1-磷酸(S1P)代谢的重要组成部分。由于SPL在S1P代谢中的作用，它与多种重要的细胞功能有关，但对其在病毒感染中的作用知之甚少。研究表明，Spl通过与IKKɛ相互作用，促进I型干扰素对甲型流感病毒感染的天然免疫应答，具有抗病毒作用。然而，最近的一项研究表明，IAV NS1蛋白通过触发泛素化和随后的SPL降解来阻碍这一过程，从而减少I型干扰素的先天免疫反应。在这项研究中，我们描述了SPL，I型干扰素反应，以及SPL和IAV之间的已知相互作用。
Sphingosine 1-phosphate lyase (SPL) is a critical component of sphingosine 1-phosphate (S1P) metabolism. SPL has been associated with several crucial cellular functions due to its role in S1P metabolism, but its role in viral infections is poorly understood. Studies show that SPL has an antiviral function against influenza A virus (IAV) by interacting with IKKɛ, promoting the type I interferon (IFN) innate immune response to IAV infection. However, a more recent study has revealed that IAV NS1 protein hampers this by triggering ubiquitination and subsequent degradation of SPL, which reduces the type I IFN innate immune response. In this study, we describe SPL, the type I IFN response, and known interactions between SPL and IAV.