The Ninth Annual American Association of cancer research international conference on frontiers in cancer prevention research.
The Ninth Annual American Association of cancer research international conference on frontiers in cancer prevention research.
复制标题
第九届美国癌症研究协会年度癌症预防研究前沿国际会议。
DOI：
10.1158/1940-6207.capr-11-0018
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Bergan,RaymondC
中科院分区：
文献类型：
--
作者：
Xu,Li;Wang,SophiaS;Healey,MeganA;Faupel-Badger,JessicaM;Wilken,JasonA;Battaglia,Tracy;Szabo,Eva;Mao,JennyT;Bergan,RaymondC
第九届AACR癌症预防前沿研究年会于2010年11月7日至10日在费城举行。其主题重点是“预防：从基础科学到公共卫生利益”。端粒可塑性、微环境、炎症、向转移表型的转化和肥胖的途径被强调为可干预的癌症发生的重要因素。来自与物理生物学、分子和基因图谱、成像以及行为和临床参数相关的新技术的信息集成，促进了风险分层和早期发现。癌症预防为发展个性化干预措施和提高药物发现效率提供了一个强大的试验场。临床试验的进展与更有效的设计策略有关，已显示出首个人类靶向能力，并已开发出强大的策略来克服应计障碍。量身定做的干预策略现在在几种癌症类型的大队列中显示出高效率。这些成功案例预计还会增加。癌症预防研究；4(4)；616-21。©2011 AACR。
The Ninth Annual AACR Frontiers in Cancer Prevention Research conference was held in Philadelphia in November 7–10, 2010. Its thematic focus was “Prevention: From Basic Science to Public Health Benefit.” Telomere plasticity, the microenvironment, inflammation, transformation to the metastatic phenotype, and pathways to obesity were highlighted as important elements of carcinogenesis amenable to intervention. The integration of information from novel technologies related to physical biology, molecular and genetic profiles, and imaging along with behavioral and clinical parameters have advanced risk stratification and early detection. Cancer prevention represents a powerful testing ground for the development of individually tailored intervention and for increasing the efficiency of drug discovery. Advances in clinical trials relate to more efficient design strategies, have shown first-in-human targeting capabilities, and have developed powerful strategies to overcome accrual barriers. Tailored intervention strategies now show high efficacy on large cohorts across several cancer types. These successes are expected to increase.Cancer Prev Res; 4(4); 616–21. ©2011 AACR.