Bone marrow-derived cells contribute to lung regeneration after elastase-induced pulmonary emphysema
Bone marrow-derived cells contribute to lung regeneration after elastase-induced pulmonary emphysema
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DOI：
10.1016/s0014-5793(03)01399-1
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发表时间：
2004-01-02
期刊：
影响因子：
3.5
通讯作者：
Sasaki, H
中科院分区：
文献类型：
--
作者：
Ishizawa, K;Kubo, H;Sasaki, H
全反式维甲酸（ATRA）被认为可以逆转肺气肿的解剖和生理体征。然而，参与肺再生的祖细胞的起源仍不清楚。最近，研究表明，骨髓可以是几种细胞类型的祖细胞的来源。用ATRA、粒细胞集落刺激因子（G-CSF）或两者联合治疗弹性蛋白酶诱导的肺气肿小鼠。ATRA或G-CSF可促进肺再生，增加肺泡内骨髓源性细胞（BMC）数量。两者联合治疗具有相加效应，这表明BMC动员在肺再生中可能是重要的。(C)2003年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
All-trans retinoic acid (ATRA) is known to reverse the anatomic and physiologic signs of pulmonary emphysema. However, the origin of the progenitor cells involved in this lung regeneration remains unclear. Recently, it was shown that bone marrow could be the source of progenitor cells for several cell types. Mice with elastase-induced emphysema were treated with ATRA, granulocyte colony-stimulating factor (G-CSF), or a combination of both. ATRA or G-CSF promoted lung regeneration and increased bone marrow-derived cell (BMC) numbers in alveoli. Combined treatment of both had an additive effect, which indicated that BMC mobilization might be important in lung regeneration. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.