Effects of Perinatal Exposure to Phthalates and a High-Fat Diet on Maternal Behavior and Pup Development and Social Play
Effects of Perinatal Exposure to Phthalates and a High-Fat Diet on Maternal Behavior and Pup Development and Social Play
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DOI：
10.1210/en.2017-03047
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发表时间：
2018-02-01
期刊：
影响因子：
4.8
通讯作者：
Juraska, Janice M.
中科院分区：
文献类型：
--
作者：
Kougias, Daniel G.;Cortes, Laura R.;Juraska, Janice M.
人类无处不在地接触到邻苯二甲酸盐，这是一种内分泌干扰化学物质，通常用于许多消费品中，而饮食，尤其是高脂肪食物，被认为是主要的接触来源。在这里，我们使用人类产前暴露的大鼠模型来研究环境相关的邻苯二甲酸盐混合物和母体高脂肪饮食（HFD）的潜在相互作用。从妊娠期到出生后第10天(P)，母鼠食用邻苯二甲酸盐混合物（0、200或1000 μ g/kg/d），并饲喂对照饲粮或HFD。在男性中，围产期接触邻苯二甲酸盐混合物会降低青春期前的体重，并以剂量特异性的方式降低青春期周围的社交游戏行为。邻苯二甲酸盐对HFD的剂量特异性影响也出现在社交活动中女性独处时间的增加。HFD导致母鼠消耗更多的卡路里，有更大的妊娠期体重增加，并且更多地舔和喂养它们的幼崽，因此，产后早期的HFD通常会增加幼崽的体重。暴露于相对高剂量邻苯二甲酸盐和HFD的雄性内侧前额皮质P10氧化应激标志物也有增加的趋势。对内侧前额叶皮层和下丘脑P10和P90基因表达的影响不一致。总的来说，本研究表明邻苯二甲酸酯和母体HFD很少相互作用，除了雄性的氧化应激标志物。此外，围产期接触与环境有关的邻苯二甲酸盐混合物可能对男性和女性的社会行为产生适度但持久的影响。
Humans are ubiquitously exposed to many phthalates, a class of endocrine-disrupting chemicals commonly used in many consumer goods, and diet, especially fatty food, is presumed to be a major source of exposure. Here, we use a rat model of human prenatal exposure to investigate the potential interactive effects of an environmentally relevant mixture of phthalates and a maternal high-fat diet (HFD). From gestation through postnatal day (P) 10, dams consumed the mixture of phthalates (0, 200, or 1000 mu g/kg/d) and were fed a control diet or HFD. In males, perinatal exposure to the mixture of phthalates decreased prepubertal body weight and, in a dose-specific manner, periadolescent social play behavior. A dose-specific effect from phthalates with HFD was also seen in increased time alone in females during social play. HFD resulted in dams consuming more calories, having greater gestational weight gain, and licking and nursing their pups more, such that an early postnatal HFD generally increased pup body weight. There also was a tendency for increased oxidative stress markers at P10 within the medial prefrontal cortex of males exposed to the relatively high dose of phthalates and HFD. Effects on gene expression were inconsistent at P10 and P90 in both the medial prefrontal cortex and hypothalamus. Overall, this study demonstrates that phthalates and a maternal HFD only rarely interacted, except in oxidative stress markers in males. Additionally, perinatal exposure to an environmentally relevant mixture of phthalates can have a modest, but lasting, impact on social behaviors in both males and females.