Genetical genomics in humans and model organisms
Genetical genomics in humans and model organisms
复制标题
DOI：
10.1016/j.tig.2005.05.004
复制
发表时间：
2005-07-01
影响因子：
11.4
通讯作者：
Haley, CS
中科院分区：
文献类型：
--
作者：
de Koning, DJ;Haley, CS
遗传基因组学已被提出用于绘制控制基因表达差异（表达数量性状基因座，eQTLs）的位点，这些位点可能是功能性状变异的基础。我们简要回顾了在模式生物中的研究，并得出结论：尽管它们成功地证明了遗传基因组学的实用性，但它们的局限性太大，无法充分发挥这种方法的潜力，并且一些结果应谨慎解读。随后我们详细阐述了最近在人类中使用这种方法的两项研究。这些研究之间的诸多差异使它们之间难以进行有意义的比较。对这两项实验的联合分析为更强大的遗传基因组学提供了一定的空间。
Genetical genomics has been proposed to map loci controlling gene-expression differences (eQTLs) that might underlie functional trait variation. We briefly review the studies in model species and conclude that, although they successfully demonstrate the utility of genetical genomics, they are too limited to unlock the full potential of this approach and some results should be interpreted with caution. We subsequently elaborate on two recent studies that use this approach in humans. The many differences between these studies complicate meaningful comparisons between them. A joint analysis of the two experiments offers some scope for more powerful genetical genomics.