Exhaustive Chemoselective Reduction of Nitriles by Catalytic Hydrosilylation Involving Cooperative Si–H Bond Activation
Exhaustive Chemoselective Reduction of Nitriles by Catalytic Hydrosilylation Involving Cooperative Si–H Bond Activation
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DOI：
10.1055/s-0036-1588441
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发表时间：
2017-05
期刊：
影响因子：
2
通讯作者：
Simon Wübbolt;M. Oestreich
中科院分区：
文献类型：
--
作者：
Simon Wübbolt;M. Oestreich
摘要本文报道了一种腈类化合物催化硅氢加成反应的化学选择性方法。化学选择性由所用的氢硅烷控制。腈到胺还原的有用性被证明为一组不同的芳香族和脂肪族腈，并且胺在水解后容易地分离为它们的盐酸盐。这种彻底的腈还原在室温下进行。
Abstract A chemoselective method for the catalytic hydrosilylation of nitriles to either the imine or amine oxidation level is reported. The chemoselectivity is controlled by the hydrosilane used. The usefulness of the nitrile-to-amine reduction is demonstrated for a diverse set of aromatic and aliphatic nitriles, and the amines are easily isolated after hydrolysis as their hydrochloride salts. This exhaustive nitrile reduction proceeds at room temperature.