Role for herpes simplex virus 1 ICP27 in the inhibition of type I interferon signaling
Role for herpes simplex virus 1 ICP27 in the inhibition of type I interferon signaling
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DOI：
10.1016/j.virol.2008.01.001
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发表时间：
2008-05-10
期刊：
影响因子：
3.7
通讯作者：
Knipe, David M.
中科院分区：
文献类型：
--
作者：
Johnson, Karen E.;Song, Byeongwoon;Knipe, David M.
Host cells respond to viral infection by many mechanisms, including the production of type I interferons which act in a paracrine and autocrine manner to induce the expression of antiviral interferon-stimulated genes (ISGs). Viruses have evolved means to inhibit interferon signaling to avoid induction of the innate immune response. Herpes simplex virus I (HSV-1) has several mechanisms to inhibit type I interferon production, the activities of ISGs, and the interferon signaling pathway itself. We report that the inhibition of the Jak/STAT pathway by HSV-1 requires viral gene expression and that viral immediate-early protein ICP27 plays a role in downregulating STAT-I phosphorylation and in preventing the accumulation of STAT-1 in the nucleus. We also show that expression of ICP27 by transfection causes an inhibition of IFN-induced STAT-1 nuclear accumulation. Therefore, ICP27 is necessary and sufficient for at least some of the effects of HSV infection on STAT-1. (C) 2008 Elsevier Inc. All rights reserved.
