Biogenesis and function of the NGF/TrkA signaling endosome.
Biogenesis and function of the NGF/TrkA signaling endosome.
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DOI：
10.1016/bs.ircmb.2014.10.002
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发表时间：
2015
影响因子：
--
通讯作者：
Li G
中科院分区：
文献类型：
--
作者：
Marlin MC;Li G
靶源性神经营养因子神经生长因子（NGF）及其受体TrkA是众所周知的逆行信号，以促进交感神经元和感觉神经元的存活和神经支配。近年来，信号内体模型已被用于描述持续的NGF/TrkA逆行信号转导，即含有NGF/TrkA的内体从轴突终末到细胞体的内吞和逆行转运过程，以激活负责神经元存活和发育的NGF诱导基因表达。本文综述了NGF、TrkA和信号内体的生物起源和功能，并讨论了Rab GTP酶在信号内体的生物起源和运输中的可能作用。
Target-derived neurotrophin nerve growth factor (NGF) and its receptor TrkA are well known for retrograde signaling to promote survival and innervation of sympathetic and sensory neurons. In recent years, the signaling endosome model has been used to describe the sustained NGF/TrkA retrograde signaling as a process of endocytosis and retrograde transport of NGF/TrkA-containing endosomes from the axon terminal to the cell body for activation of NGF-inducible gene expression responsible for neuronal survival and development. Here, we review the biogenesis and function of NGF, TrkA, and the signaling endosome and discuss possible roles of Rab GTPases in the biogenesis and trafficking of signaling endosomes.