Influence of hyaluronic acid on the time-dependent friction response of articular cartilage under different conditions
Influence of hyaluronic acid on the time-dependent friction response of articular cartilage under different conditions
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DOI：
10.1243/095441105x69060
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发表时间：
2006-01-01
期刊：
影响因子：
1.8
通讯作者：
Fisher, J
中科院分区：
文献类型：
--
作者：
Bell, CJ;Ingham, E;Fisher, J
透明质酸润滑剂注射治疗是一种相对较新的骨关节炎治疗方法。然而，它们在体内的功效受到了很多争议。已经使用健康的软骨和具有物理破坏表面的软骨，添加或不添加治疗性润滑剂透明质酸，研究了静态和动态负载条件下软骨-软骨接触的摩擦特性。大多数软骨摩擦模型产生了典型的时间依赖性负载曲线，静摩擦力随着负载时间的增加而增加。对于动态负载条件，摩擦随负载时间的增加取决于软骨板上负载的空间（和时间）变化。对于4毫米或更大的滑动距离，当软骨板在滑动过程中卸载时，动摩擦保持较低，而当滑动距离较短时，动摩擦随着加载时间的增加而增加。静摩擦高于动摩擦（在相同的摩擦学条件下）。在同等摩擦学条件下，“受损”软骨模型比健康软骨产生更高的摩擦力。结果表明，在健康和受损软骨表面的静态条件下，透明质酸是关节软骨的有效边界润滑剂。透明质酸在动态条件下效果较差。然而，由于软骨固有双相润滑的有效性，这些动态条件与控制润滑剂的摩擦值较低。只有在摩擦学条件下，由于内在双相润滑的消耗，软骨摩擦力较高并且随着加载时间的增加而增加，透明质酸作为有效治疗润滑剂的作用才得以证明。
Therapeutic lubricant injections of hyaluronic acid are a relatively recent treatment for osteoarthritis. Their efficacy, however, in vivo has been subject to much debate.Frictional properties of cartilage-cartilage contacts under both static and dynamic loading conditions have been investigated, using healthy cartilage and cartilage with a physically disrupted surface, with and without the addition of a therapeutic lubricant, hyaluronic acid.Most of the cartilage friction models produced typical time-dependent loading curves, with a rise in static friction with loading time. For the dynamic loading conditions the rise in friction with loading time was dependent on the spatial (and time) variation in the load on the cartilage plate. For sliding distances of 4 mm or greater, when the cartilage plate was unloaded during sliding, the dynamic friction remained low whereas, with shorter sliding distances, the dynamic friction increased with increasing loading time. Static friction was higher than dynamic friction (under the same tribological conditions). The 'damaged' cartilage models produced higher friction than healthy cartilage under equivalent tribological conditions.It was shown that hyaluronic acid was an effective boundary lubricant for articular cartilage under static conditions with both healthy and damaged cartilage surfaces. Hyaluronic acid was less effective under dynamic conditions. However, these dynamic conditions had low friction values with the control lubricant because of the effectiveness of the intrinsic biphasic lubrication of the cartilage. It was only under the tribological conditions in which the cartilage friction was higher and rising with increasing loading time because of depletion of the intrinsic biphasic lubrication, that the role of hyaluronic acid as an effective therapeutic lubricant was demonstrated.