SEROLOGICAL RESPONSES TO BRUCELLOSIS IN HIV-SEROPOSITIVE PATIENTS
SEROLOGICAL RESPONSES TO BRUCELLOSIS IN HIV-SEROPOSITIVE PATIENTS
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DOI：
10.1016/0035-9203(95)90508-1
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发表时间：
1995-03-01
影响因子：
2.2
通讯作者：
SELKON, JB
中科院分区：
文献类型：
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作者：
PAUL, J;GILKS, C;SELKON, JB
采用酶联免疫吸附试验（ELISA）检测了2例在肯尼亚内罗毕某诊所就诊的人类免疫缺陷病毒（HIV）1型感染患者的系列血清，并检测了其对布鲁氏菌感染的血清学应答（布鲁氏菌特异性免疫球蛋白（IG）M和IgG）。抗体应答与免疫功能正常的个体相当，一名患者显示急性布鲁氏菌病的典型血清学，另一名患者显示慢性布鲁氏菌病。来自100名其他患者的血清，其中65人是HIV阳性，参加同一诊所，但其常规微生物培养阴性的布鲁氏菌，进行了回顾性布鲁氏菌特异性抗体检测。8例有布鲁氏菌特异性IgM和IgG，6例仅IgM，21例仅IgG，表明研究队列中布鲁氏菌暴露水平相对较高。布鲁氏菌抗体状态和HIV状态之间没有关联。布鲁氏菌病在肯尼亚可能诊断不足。布鲁氏菌血清学可能有助于东非非特异性症状患者的诊断，无论HIV状态如何。
Serial sera from 2 patients infected with the human immunodeficiency virus (HIV) type 1 attending a clinic in Nairobi, Kenya, and with blood cultures yielding Brucella melitensis, were tested by enzyme-linked immunosorbent assay for their serological response (Brucella-specific immunoglobulin (Ig) M and IgG) to Brucella infection. Antibody responses were comparable to those of immunocompetent individuals, one patient showing serology typical of acute brucellosis, the other of chronic brucellosis. Sera from 100 other patients, 65 of whom were HIV-positive, attending the same clinic but whose routine microbiological cultures were negative for Brucella, were tested retrospectively for Brucella-specific antibody. Eight had Brucella-specific IgM and IgG, 6 had IgM only and 21 had IgG only, suggesting relatively high levels of exposure to Brucella in the study cohort. There was no association between Brucella antibody status and HIV status. Brucellosis is probably underdiagnosed in Kenya. Brucella serology may be helpful in the diagnosis of patients with non-specific symptoms in East Africa, regardless of HIV status.