Energy metabolism differs between sleep stages and begins to increase prior to awakening
Energy metabolism differs between sleep stages and begins to increase prior to awakening
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DOI：
10.1016/j.metabol.2016.12.016
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发表时间：
2017-04-01
影响因子：
9.8
通讯作者：
Tokuyama, Kumpei
中科院分区：
文献类型：
--
作者：
Kayaba, Momoko;Park, Insung;Tokuyama, Kumpei
目的.人类的睡眠通常被合并成一个单一的长时间，其代谢的后果是强加一个长时间的禁食。睡眠开始后睡眠阶段和稳态睡眠驱动的变化可能通过控制能量代谢和睡眠的机制之间的相互作用影响睡眠代谢率。本研究的目的是分离睡眠阶段和入睡后时间对睡眠代谢率的影响。采用全室间接测热法测定29名健康成人的睡眠代谢率，同时进行多导睡眠图记录。采用半参数回归分析评价睡眠阶段和入睡后时间对睡眠代谢率的影响。睡眠阶段的影响采用参数分析，时间的影响采用非参数分析。能量消耗在睡眠阶段之间存在显著差异：入睡后觉醒（WASO）>第2阶段，慢波睡眠（SWS）和REM;第1阶段>第2阶段和SWS; REM > SWS。类似地，碳水化合物氧化在睡眠阶段之间存在显著差异：WASO >阶段2和SWS;以及阶段1 > SWS。能量消耗和碳水化合物氧化在睡眠的前半段下降，随后在睡眠的后半段增加。这项研究确定了能量消耗和碳水化合物氧化的特征表型，表明睡眠代谢率在睡眠阶段之间存在差异。(C)2017爱思唯尔公司All rights reserved.
Purpose. Human sleep is generally consolidated into a single prolonged period, and its metabolic consequence is to impose an extended period of fasting. Changes in sleep stage and homeostatic sleep drive following sleep onset may affect sleeping metabolic rate through cross talk between the mechanisms controlling energy metabolism and sleep. The purpose of this study was to isolate the effects of sleep stage and time after sleep onset on sleeping metabolic rate.Methods. The sleeping metabolic rate of 29 healthy adults was measured using whole room indirect calorimetry, during which polysomnographic recording of sleep was performed. The effects of sleep stage and time after sleep onset on sleeping metabolic rate were evaluated using a semi-parametric regression analysis. A parametric analysis was used for the effect of sleep stage and a non-parametric analysis was used for the effect of time.Results. Energy expenditure differed significantly between sleep stages: wake after sleep onset (WASO) > stage 2, slow wave sleep (SWS), and REM; stage 1 > stage 2 and SWS; and REM > SWS. Similarly, carbohydrate oxidation differed significantly between sleep stages: WASO > stage 2 and SWS; and stage 1 > SWS. Energy expenditure and carbohydrate oxidation decreased during the first half of sleep followed by an increase during the second half of sleep.Conclusions. This study identified characteristic phenotypes in energy expenditure and carbohydrate oxidation indicating that sleeping metabolic rate differs between sleep stages. (C) 2017 Elsevier Inc. All rights reserved.