Functional role of insulin-like growth factor binding proteins
Functional role of insulin-like growth factor binding proteins
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DOI：
10.1159/000191304
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发表时间：
1997-01-01
期刊：
影响因子：
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通讯作者：
Elmlinger, M
中科院分区：
文献类型：
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作者：
Ranke, MB;Elmlinger, M
胰岛素样生长因子（IGF-I，IGF-II）是细胞分裂和分化的重要调节因子。在其游离形式下，IGFs与特异性结合蛋白（IGFBPs）形成复合物，其中六种现已被表征。这些IGFBPs结合IGF-I和/或IGF-II的能力不同，并且根据其位置和代谢情况，它们在不同程度上抑制或增强IGF作用。新的发现改变了我们对IGFBPs的理解，IGFBPs现在被认为是IGF作用和隔室之间IGF转运蛋白的主要调节剂。最近，IGFBPs的ICF独立作用被发现。例如，IGFBP-3的水平是改变生长激素分泌和作用状态的重要指标，并且在用生长激素或IGF-I治疗期间是重要的。IGFBP-1和-2水平反映了与营养、胰岛素分泌、胎儿发育和恶性状态相关的变化。IGFs、IGFBPs及其靶点之间复杂相互作用的揭示必将影响我们对生物系统生理学和发育的理解。同样，调控IGFBP系统的可能性可能会在未来开辟疾病治疗的新领域。
Insulin-like growth factors (IGF-I, IGF-II) are important regulators of cell division and differentiation. In their free form, IGFs form a complex with specific binding proteins (IGFBPs), six of which have now been characterized. These IGFBPs differ in their ability to bind IGF-I and/or IGF-II, and, depending on their location and metabolic circumstances, they inhibit or augment IGF action to varying extents. New findings have changed our understanding of IGFBPs, which are now considered to be major regulators of IGF action and IGF transport proteins between compartments. Recently, the ICF-independent action of IGFBPs was discovered. Levels of IGFBP-3, for instance, are important indicators of states of altered growth hormone secretion and action, as well as being important during treatment with growth hormone or IGF-I. IGFBP-1 and -2 levels reflect changes related to nutrition, insulin secretion, foetal development and malignant state. The unravelling of the intricate interactions of IGFs, IGFBPs and their targets is bound to influence our understanding of the physiology and development of biological systems. Likewise, the possibility of regulating the IGFBP system is likely to open up new fields in the treatment of diseases in the future.