Progressive periodontal disease and risk of very preterm delivery
Progressive periodontal disease and risk of very preterm delivery
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DOI：
10.1097/01.aog.0000190212.87012.96
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发表时间：
2006-01-01
影响因子：
7.2
通讯作者：
Beck, JD
中科院分区：
文献类型：
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作者：
Offenbacher, S;Boggess, KA;Beck, JD
目的：我们的目标是估计是否产妇牙周病是预测早产（小于37周）或非常早产（小于32周）births.METHODS：一项前瞻性研究的产科结局，题为口腔条件和妊娠（OCAP），进行了1,020名孕妇谁收到产前和产后牙周检查。预测模型被开发来估计是否母亲暴露于牙周病在登记（小于26周）和/或牙周疾病进展，通过比较产后和产前状态确定，是早产或极早产的预测因素，调整风险因素包括以前的早产，种族，吸烟，社会领域的变量，和其他感染。牙周健康妇女的早产发生率为11.2%，而中重度牙周病妇女的早产发生率为28.6%（调整后的风险比[RR] 1.6，95%置信区间[CI] 1.1-2.3）。产前中重度牙周病与自发性早产发生率增加相关（15.2%对24.9%，调整后RR 2.0，95%CI 1.2-3.2）。同样，未经调整的比率非常早产的妇女与牙周疾病进展的6.4%，显着高于1.8%的妇女没有疾病进展（调整后的RR 2.4，95%CI 1.1-5.2）。结论：OCAP研究表明，产妇牙周疾病增加早产或自发性早产的相对风险。此外，妊娠期围钟疾病进展是极早产更严重不良妊娠结局的预测因子，独立于传统的产科、牙周和社会领域风险因素。
OBJECTIVE: The goal was to estimate whether maternal periodontal disease was predictive of preterm (less than 37 weeks) or very preterm (less than 32 weeks) births.METHODS: A prospective study of obstetric outcomes, entitled Oral Conditions and Pregnancy (OCAP), was conducted with 1,020 pregnant women who received both an antepartum and postpartum periodontal examination. Predictive models were developed to estimate whether maternal exposure to either periodontal disease at enrollment (less than 26 weeks) and/or periodontal disease progression during pregnancy, as determined by comparing postpartum with antepartum status, were predictive of preterm or very preterm births, adjusting for risk factors including previous preterm delivery, race, smoking, social domain variables, and other infections.RESULTS: Incidence of preterm birth was 11.2% among periodontally healthy women, compared with 28.6% in women with moderate-severe periodontal disease (adjusted risk ratio [RR] 1.6, 95% confidence interval [CI] 1.1-2.3). Antepartum moderate-severe periodontal disease was associated with an increased incidence of spontaneous preterm births (15.2% versus 24.9%, adjusted RR 2.0, 95% CI 1.2-3.2). Similarly, the unadjusted rate of very preterm delivery was 6.4% among women with periodontal disease progression, significantly higher than the 1.8% rate among women without disease progression (adjusted RR 2.4, 95% CI 1.1-5.2).CONCLUSION: The OCAP study demonstrates that maternal periodontal disease increases relative risk for preterm or spontaneous preterm births. Furthermore, perioclontal disease progression during pregnancy was a predictor of the more severe adverse pregnancy outcome of very preterm birth, independently of traditional obstetric, periodontal, and social domain risk factors.