Liposome: classification, preparation, and applications.
Liposome: classification, preparation, and applications.
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DOI：
10.1186/1556-276x-8-102
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发表时间：
2013-02-22
影响因子：
--
通讯作者：
Nejati-Koshki K
中科院分区：
文献类型：
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作者：
Akbarzadeh A;Rezaei-Sadabady R;Davaran S;Joo SW;Zarghami N;Hanifehpour Y;Samiei M;Kouhi M;Nejati-Koshki K
脂质体，由一个或多个磷脂双层组成的球形囊泡，最早在60年代中期被描述。今天，它们是各种科学学科中非常有用的复制，试剂和工具，包括数学和理论物理，生物物理，化学，胶体科学，生物化学和生物学。从那时起，脂质体就进入了市场。在几种有才华的新型药物递送系统中，脂质体表征了将活性分子递送到作用部位的先进技术，目前，几种制剂已在临床上使用。脂质体技术的研究已经从传统的囊泡发展到“第二代脂质体”，其中通过调节囊泡的脂质组成、大小和电荷来获得长循环脂质体。也已经使用几种分子如糖脂或唾液酸开发了具有改性表面的脂质体。本文总结了专门的可扩展技术，并侧重于优势，分别在工业适用性和监管要求方面的限制，脂质体药物制剂的基础上，FDA和EMEA的文件。
Liposomes, sphere-shaped vesicles consisting of one or more phospholipid bilayers, were first described in the mid-60s. Today, they are a very useful reproduction, reagent, and tool in various scientific disciplines, including mathematics and theoretical physics, biophysics, chemistry, colloid science, biochemistry, and biology. Since then, liposomes have made their way to the market. Among several talented new drug delivery systems, liposomes characterize an advanced technology to deliver active molecules to the site of action, and at present, several formulations are in clinical use. Research on liposome technology has progressed from conventional vesicles to ‘second-generation liposomes’, in which long-circulating liposomes are obtained by modulating the lipid composition, size, and charge of the vesicle. Liposomes with modified surfaces have also been developed using several molecules, such as glycolipids or sialic acid. This paper summarizes exclusively scalable techniques and focuses on strengths, respectively, limitations in respect to industrial applicability and regulatory requirements concerning liposomal drug formulations based on FDA and EMEA documents.