Hierarchical nesting of slow oscillations, spindles and ripples in the human hippocampus during sleep
Hierarchical nesting of slow oscillations, spindles and ripples in the human hippocampus during sleep
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DOI：
10.1038/nn.4119
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发表时间：
2015-11-01
影响因子：
25
通讯作者：
Fell, Juergen
中科院分区：
文献类型：
--
作者：
Staresina, Bernhard P.;Bergmann, Ti Ole;Fell, Juergen
在系统水平的巩固过程中，最初依赖于海马体的记忆表征被认为会迁移到新皮质部位进行更永久的存储，睡眠在促进这种信息传递方面发挥了重要作用。从机制上讲，巩固过程已被假设依赖于表征非快速眼动（NREM）睡眠的三个主要神经元振荡之间的系统性相互作用。在去极化和超极化慢振荡（SO）的全局控制下，睡眠纺锤波可以聚集海马波纹，以便将局部信息精确定时地传递到新皮层。我们使用人类癫痫患者在自然睡眠期间的直接颅内脑电图记录来测试SO，纺锤波和波纹在海马中功能耦合的假设。采用交叉频率相位振幅耦合分析，我们发现，纺锤体调制的SO的上状态。值得注意的是，纺锤波被发现反过来集群波纹在其槽，提供微调的时间框架的假设转移海马记忆痕迹。
During systems-level consolidation, mnemonic representations initially reliant on the hippocampus are thought to migrate to neocortical sites for more permanent storage, with an eminent role of sleep for facilitating this information transfer. Mechanistically, consolidation processes have been hypothesized to rely on systematic interactions between the three cardinal neuronal oscillations characterizing non-rapid eye movement (NREM) sleep. Under global control of de- and hyperpolarizing slow oscillations (SOs), sleep spindles may cluster hippocampal ripples for a precisely timed transfer of local information to the neocortex. We used direct intracranial electroencephalogram recordings from human epilepsy patients during natural sleep to test the assumption that SOs, spindles and ripples are functionally coupled in the hippocampus. Employing cross-frequency phase-amplitude coupling analyses, we found that spindles were modulated by the up-state of SOs. Notably, spindles were found to in turn cluster ripples in their troughs, providing fine-tuned temporal frames for the hypothesized transfer of hippocampal memory traces.