BAG-1 induces autophagy for cardiac cell survival
BAG-1 induces autophagy for cardiac cell survival
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DOI：
10.4161/auto.5.1.7303
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发表时间：
2009-01-01
期刊：
影响因子：
13.3
通讯作者：
Das, Dipak K.
中科院分区：
文献类型：
--
作者：
Gurusamy, Narasimman;Lekli, Istyan;Das, Dipak K.
BAG(BAG)蛋白家族通过连接招募分子伴侣的分子与靶蛋白起到辅助伴侣的作用。BAG-1在热休克蛋白Hsc70/Hsp70和蛋白酶体之间提供物理联系，以促进泛素-蛋白酶体介导的蛋白质降解。除了蛋白酶体外，通过自噬的蛋白质降解还负责维持细胞代谢、细胞器动态平衡和氧化还原平衡。我们最近的报告表明，自噬在心脏适应性诱导的细胞抗缺血再灌注损伤中发挥着重要作用，与BAG-1蛋白有关。BAG-1与自噬体膜蛋白LC3-II有关，它可能通过Hsc70参与自噬的诱导。此外，另一个Bag家族成员Bag-3负责与HspB8相关的巨型自噬的诱导。这些结果表明，BAG家族成员参与了自噬的诱导，以降解受损或氧化的蛋白质，促进细胞存活。
The Bcl-2 associated athanogene (BAG) family of proteins function as cochaperones by bridging molecules that recruit molecular chaperones to target proteins. BAG-1 provides a physical link between the heat shock proteins Hsc70/Hsp70 and the proteasome to facilitate ubiquitin-proteasome-mediated protein degradation. In addition to the proteasome, protein degradation via autophagy is responsible for maintaining cellular metabolism, organelle homeostasis and redox equilibrium. Our recent report shows that autophagy plays an important role in cardiac adaptation-induced cell survival against ischemia-reperfusion injury in association with the BAG-1 protein. BAG-1 is associated with the autophagosomal membrane protein LC3-II and it may participate in the induction of autophagy via Hsc70. Moreover, another BAG family member, BAG-3, is responsible for the induction of macroautophagy in association with HspB8. These results show the involvement of BAG family members in the induction of autophagy for the degradation of damaged or oxidized proteins to promote cell survival.