Inhibitory effect of ferulic acid and isoferulic acid on the production of macrophage inflammatory protein-2 in response to respiratory syncytial virus infection in RAW264.7 cells
Inhibitory effect of ferulic acid and isoferulic acid on the production of macrophage inflammatory protein-2 in response to respiratory syncytial virus infection in RAW264.7 cells
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DOI：
10.1080/09629359990513
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发表时间：
1999-01-01
影响因子：
4.6
通讯作者：
Ochiai, H
中科院分区：
文献类型：
--
作者：
Sakai, S;Kawamata, H;Ochiai, H
我们研究了阿魏酸（FA）和异阿魏酸（IFA）对呼吸道合胞病毒（RSV）感染小鼠巨噬细胞系RAW 264.7中巨噬细胞炎性蛋白-2（MIR-2）产生的影响，在细胞暴露于RSV 20小时后，条件培养基中的MIP-2水平增加至约20 ng/ml，尽管在模拟感染的细胞中该水平可忽略不计。在FA或IFA存在下，RSV感染的细胞以剂量依赖性方式减少MIP-2产生。这些数据表明FA和IFA可能至少部分地负责，CH提取物通过抑制MIP-2的产生而发挥抗炎药物作用。
WE investigated the effect of ferulic acid (FA) and isoferulic acid (IFA), which are the main active components of the rhizoma of Cimicifuga heracleifolia (CH), an anti-inflammatory drug used frequently in Japanese traditional medicine, on the production of macrophage inflammatory protein-2 (MIR-2) in a murine macrophage cell line, RAW264.7, in response to respiratory syncytial virus (RSV) infection, Following the exposure of cells to RSV for 20 h, the MIP-2 level in condition medium was increased to about 20 ng/ml, although this level in mock-infected cells was negligible, In the presence of either FA or IFA, RSV-infected cells reduced MIP-2 production in a dose-dependent manner, These data suggest that FA and IFA might be responsible, at least in part, for the anti-inflammatory drug effect of CH extract through the inhibition of MIP-2 production.