Axonal projections from the organum vasculosum lamina terminalis to the supraoptic nucleus: Functional analysis and presynaptic modulation
Axonal projections from the organum vasculosum lamina terminalis to the supraoptic nucleus: Functional analysis and presynaptic modulation
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DOI：
10.1046/j.1440-1681.2001.03488.x
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发表时间：
2001-07-01
影响因子：
2.9
通讯作者：
Richard, D
中科院分区：
文献类型：
--
作者：
Bourque, CW;Richard, D
1.大鼠终板血管器（OVLT）含有GABA和谷氨酸释放神经元，这些神经元直接投射到视上核的大细胞神经分泌细胞（MNC）.下丘脑移植物中渗透压在OVLT以上的变化通过相应的自发性突触后兴奋电位频率的变化引起MNC放电的比例变化，而不影响GABA能抑制性突触后电位.外源性应用心房利钠肽通过引起由源自OVLT神经元的动作电位引起的谷氨酸释放量减少来抑制MNC的渗透控制。
1. The rat organum vasculosum lamina terminalis (OVLT) contains GABA- and glutamate-releasing neurons that project directly to magnocellular neurosecretory cells (MNC) in the supraoptic nucleus.2. Changes in osmolality over the OVLT in hypothalamic explants cause proportional changes in firing in MNC through corresponding changes in the frequency of spontaneous glutamatergic excitatory post-synaptic potentials without affecting GABAergic inhibitory post-synaptic potentials.3. Exogenously applied atrial natriuretic peptide inhibits the osmotic control of MNC by causing a decrease in the amount of glutamate released provoked by action potentials originating from OVLT neurons.