The quality of pediatric burn scars is improved by early administration of basic fibroblast growth factor
The quality of pediatric burn scars is improved by early administration of basic fibroblast growth factor
复制标题
DOI：
10.1097/01.bcr.0000216742.23127.7a
复制
发表时间：
2006-05-01
影响因子：
1.4
通讯作者：
Hirano, Akiyoshi
中科院分区：
文献类型：
--
作者：
Akita, Sadanori;Akino, Kozo;Hirano, Akiyoshi
小儿烧伤伤口可能存在问题，因为由于解剖学上不成熟的脉管系统或固定失败而难以准确评估，特别是在二度烧伤患者中，并且因为烧伤表面积和烧伤深度往往随着时间的推移而恶化。延迟的伤口愈合导致难看的瘢痕形成，例如增生性瘢痕，这在美学和功能上都是有问题的。在细胞因子和生长因子中，碱性成纤维细胞生长因子（bFGF）在临床上得到证实，已经证明加速急性和慢性伤口愈合。加速伤口愈合可能导致改善疤痕。为了阐明bFGF对小儿二度烧伤创面的作用，进行了比较研究。将20例因各种原因烧伤的患儿分为两组，常规组（n = 10）和bFGF治疗组（n = 10）。一个水分计，用于客观地测量角质层和上皮间质功能，被用来评估疤痕至少一年后伤口愈合。对色素沉着、柔韧性、高度和血管分布的临床评价表明，传统和bFGF治疗的瘢痕之间存在显著差异（1.7 +/- 0.55 vs 0.7 +/- 0.58，2.4 +/- 0.82 vs 1.1 +/- 0.69，1.8 +/- 0.66 vs 0.5 +/- 0.57，1.9 +/- 0.63 vs 0.8 +/- 0.68;常规与bFGF处理的相比，色素沉着、柔韧性、身高和血管分布分别为P <0.01）。传统伤口的有效接触系数显著高于bFGF治疗伤口（14.6 +/-1.68%对8. 7 +/-2. 82%;传统与bFGF，P <0.01），bFGF治疗的伤口表现出比常规治疗显著更少的经表皮水分流失值（8.3 +/- 1.90 g/m2/h vs 5.7 +/- 1.85 g/m2/h;常规vs bFGF，P <0.01）。在临床评估和水分仪分析中，使用bFGF治疗的小儿烧伤患者在愈合后显示出较少的角质层破坏功能。
Pediatric burn wounds can be problematic because an accurate evaluation is difficult as the result of anatomically immature vasculature or immobilization failure, especially in patients with second-degree burns, and because the burn surface areas and the burn depth tend to worsen over the course of time. Delayed wound healing results in unsightly scarring, such as hypertrophic scars, which are problematic both esthetically and functionally. Among cytokines and growth factors, basic fibroblast growth factor (bFGF) is clinically proven, having demonstrated accelerated acute and chronic wound healing. Accelerated wound healing may lead to improved scarring. To elucidate the effects of bFGF on second-degree pediatric burn wounds, a comparative study was performed. A total of 20 pediatric patients ranging from 8 month to 3 years (average 1 year, 3 months L 6 months) who suffered from the burns by various causes were divided into two groups, conventional (n = 10) and treatment with bFGF (n = 10). A moisture meter, used to objectively measure the stratum corneum and epithelial-mesenchymal functions, was used to assess scars at least I year after wound healing. Clinical evaluation of pigmentation, pliability, height, and vascularity demonstrated significant differences between conventional and bFGF-treated scars (1.7 +/- 0.55 vs 0.7 +/- 0.58, 2.4 +/- 0.82 vs 1.1 +/- 0.69, 1.8 +/- 0.66 vs 0.5 +/- 0.57, 1.9 +/- 0.63 vs 0.8 +/- 0.68; conventional vs bFGF-treated, pigmentation, pliability, height, and vascularity, respectively, P < .01). The effective contact coefficient was significantly greater in conventional wounds than bFGF-treated wounds (14.6 +/- 1.68 % vs 8.7 +/- 2.82 %; conventional vs bFGF, P < .01) and bFGF-treated wounds demonstrated significantly less transepidermal water loss values than conventional treatment (8.3 +/- 1.90 g/m(2)/h vs 5.7 +/- 1.85 g/m(2)/hr; conventional vs bFGF, P < .01). Pediatric burn patients treated with bFGF showed less damaging function of the stratum corneum after healing both in clinical assessment and moisture meter analysis.