Photoacoustic imaging and temperature measurement for photothermal cancer therapy
Photoacoustic imaging and temperature measurement for photothermal cancer therapy
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DOI：
10.1117/1.2940362
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发表时间：
2008-05-01
影响因子：
3.5
通讯作者：
Emelianov, Stanislav Y.
中科院分区：
文献类型：
--
作者：
Shah, Jignesh;Park, Suhyun;Emelianov, Stanislav Y.
光热疗法是一种无创、靶向、基于激光的癌症治疗技术。在光热治疗期间，光能通过肿瘤特异性光吸收剂转化为热量。相应的温度升高会导致局部癌症破坏。然而，为了有效治疗，需要光吸收剂的存在。必须在治疗前确定肿瘤中的热成像，并且必须在治疗期间进行热成像。本研究探讨了通过使用光声成像检测光吸收剂和监测温度升高来指导光热治疗的可行性。光热疗法是利用连续波激光和在近红外光学范围内广泛吸收的金属纳米复合材料进行的。基于线性阵列的超声成像系统与纳秒脉冲激光连接，在光热治疗之前和期间对模拟组织模型和离体动物组织进行成像。在开始治疗之前，光声成像可识别纳米颗粒的存在和空间位置。通过监测治疗过程中温度引起的光声信号变化来计算热图，并将其与从超声成像获得的温度估计值进行比较。我们的研究结果表明，通过超声成像增强的光声成像是指导光吸收剂增强光热治疗的可行候选者。 (c) 2008 年光电仪器工程师协会。
Photothermal therapy is a noninvasive, targeted, laser-based technique for cancer treatment. During photothermal therapy, light energy is converted-to heat by tumor-specific photoabsorbers. The corresponding temperature rise causes localized cancer destruction. For effective treatment, however, the presence of photoabsorbers. in the tumor must be ascertained before therapy and thermal imaging must be performed during therapy. This study investigates the feasibility of guiding photothermal therapy by using photoacoustic imaging to detect photoabsorbers and to monitor temperature elevation. Photothermal therapy is carried out by utilizing a continuous wave laser and metal nanocomposites broadly absorbing in the near-infrared optical range. A linear array-based ultrasound imaging system is interfaced with a nanosecond pulsed laser to image tissue-mimicking phantoms and ex-vivo animal tissue before and during photothermal therapy. Before commencing therapy, photoacoustic imaging identifies the presence and spatial location of nanoparticles. Thermal maps are computed by monitoring temperature-induced changes in the photoacoustic signal during the therapeutic procedure and are compared with temperature estimates obtained from ultrasound imaging. The results of our study suggest that photoacoustic imaging, augmented by ultrasound imaging, is a viable candidate to guide photoabsorber-enhanced photothermal therapy. (c) 2008 Society of Photo-Optical instrumentation Engineers.