Using Fluorescence to Enable Innovative Functions of Foldamers
Using Fluorescence to Enable Innovative Functions of Foldamers
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DOI：
10.1002/ijch.202000109
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发表时间：
2021-02
影响因子：
3.2
通讯作者：
Amelia A. Fuller;Jose L. Moreno;M. Nguyen
中科院分区：
文献类型：
--
作者：
Amelia A. Fuller;Jose L. Moreno;M. Nguyen
单分散、序列特异性的低聚物采用规则的三维结构，称为折叠体，已被广泛用于仿生、传感器和新型材料。本文重点介绍了稳态和时间分辨荧光技术澄清了折叠分子的结构或使具有兴奋和复杂功能的折叠分子的发展成为可能的最新例子。叶酰胺的应用包括开发生物活性化合物、超分子宿主或传感器以及具有有用光学性能的材料。举例说明了天然荧光和荧光团修饰的Folamer的使用，以及荧光团与各种染料相互作用的研究。
Monodisperse, sequence‐specific oligomers that adopt regular three‐dimensional structures, termed foldamers, have found widespread use as biomimetics, sensors, and novel materials. This review highlights recent examples in which steady state and time‐resolved fluorescence techniques have clarified foldamer structure or enabled the development of foldamers with exciting and sophisticated functions. Applications of foldamers include their development into bioactive compounds, supramolecular hosts or sensors, and materials with useful optical properties. Examples that illustrate the use of natively fluorescent and fluorophore‐modified foldamers are discussed along with studies of fluorophore interactions with varied dyes.