EPIDEMIOLOGY OF PERTUSSIS, ATLANTA, 1977
EPIDEMIOLOGY OF PERTUSSIS, ATLANTA, 1977
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DOI：
10.1016/s0022-3476(81)80696-8
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发表时间：
1981-01-01
影响因子：
5.1
通讯作者：
FRASER, DW
中科院分区：
文献类型：
--
作者：
BROOME, CV;PREBLUD, SR;FRASER, DW
4月至10月1977年，在一家大型城市医院的门诊人群中流行的百日咳涉及115例通过培养或直接荧光抗体[FA]试验诊断的病例。一项对家庭接触者继发病例的研究表明，1岁以下儿童的发病率为81%；20岁以上儿童的发病率随年龄增长而下降至8%。疫苗效力估计为63%。没有证据表明，随着接种时间的延长，疫苗的效果会降低。14名无症状FA阳性者被确认；4名培养阳性。其中4人是成年人，10人是儿童。在10名儿童中，9名接受了3次或3次以上的疫苗接种，而78名有症状的儿童中有29名接受了疫苗接种(P=0.002)。
From April-Oct. 1977, an epidemic of pertussis in the outpatient population of a large metropolitan hospital involved 115 cases that were diagnosed by culture or direct fluorescent antibody [FA] tests. A study of secondary cases in household contacts showed attack rates of 81% in children under 1 yr old; attack rates decreased with increasing age to 8% in persons over 20 yr old. Vaccine efficacy was estimated to be 63%. There was no evidence of decreased efficacy with increasing time after vaccination. Fourteen asymptomatic FA-positive individuals were identified; 4 were also culture positive. Four were adults and 10 were children. Of the 10 children, 9 received 3 or more vaccinations, compared to 29 of 78 symptomatic children (P = 0.002).