Influence of Satiety and Subjective Valence Rating on Cerebral Activation Patterns in Response to Visual Stimulation with High-Calorie Stimuli among Restrictive Anorectic and Control Women
Influence of Satiety and Subjective Valence Rating on Cerebral Activation Patterns in Response to Visual Stimulation with High-Calorie Stimuli among Restrictive Anorectic and Control Women
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DOI：
10.1159/000319360
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发表时间：
2010-01-01
影响因子：
3.2
通讯作者：
Herpertz, Stephan
中科院分区：
文献类型：
--
作者：
Gizewski, Elke R.;Rosenberger, Christina;Herpertz, Stephan
背景：有证据表明神经性厌食症(AN)患者对视觉食物刺激的反应表现出特定的大脑激活模式。我们推测，大脑激活模式可以代表在饥饿和饱腹期间对高卡路里图像的不同感知，并可以由患者的主观评级确定。方法：对12例女性AN患者和12例正常体重女性分别在饥饿6h和饱食状态下进行高热量食物功能磁共振成像检查。所有患者均患有限制性AN。评估心率、饱腹感的主观评分和视觉刺激的效价。结果：饥饿状态下出现的食物刺激与对照组的前扣带回皮质和岛叶，以及AN组的前额叶、中央皮质和岛叶的激活有关。在饥饿状态下，与对照组相比，背侧后扣带回皮质激活。在饱足状态下，AN组可见左侧脑岛的激活。使用食物价格判断作为协变量，证实了脑岛的激活，并揭示了眶前叶、扣带回和内侧颞叶皮质的额外激活。结论：我们的结果表明，由于饥饿或饱腹感调节的高卡路里食物形象的不同感知，受食物价格主观评级调节的患者的大脑激活模式不同。版权所有(C)2010 S.Karger AG，巴塞尔
Background: There is evidence that patients with anorexia nervosa (AN) demonstrate specific cerebral activation patterns in response to visual food stimulation. We postulated that cerebral activation patterns could represent different perceptions of high-calorie images during hunger and satiety and could be determined by patients' subjective ratings. Methods: After 6 h of starvation and also in a state of satiety, 12 female patients with AN and 12 normal-weight women were assessed by use of fMRI with high-calorie food images. All patients suffered from a restrictive type of AN. Heart rates, subjective ratings of satiety and valences of the visual stimuli were assessed. Results: Food stimuli presented during a state of hunger were associated with significant activation of the anterior cingulate cortex and insula in the control group and of the prefrontal and central cortices and insula in the AN group. During the hunger state activation in AN of the dorsal posterior cingulate cortex was revealed compared to the controls. In the state of satiety, activation of the left insula was observed in the AN group. Use of the food valence judgment as a covariate confirmed the insula activation and revealed additional activation of the orbitofrontal, cingulate and medial temporal cortices. Conclusion: Our results indicate differences in cerebral activation patterns due to different perceptions of high-calorie food images, modulated by feelings of hunger or satiety, among AN patients with modulation by subjective ratings of food valence. Copyright (C) 2010 S. Karger AG, Basel