Hepatitis C virus enhances incidence of idiopathic pulmonary fibrosis
Hepatitis C virus enhances incidence of idiopathic pulmonary fibrosis
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DOI：
10.3748/wjg.14.5880
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发表时间：
2008-10-14
影响因子：
4.3
通讯作者：
Kumada, Hiromitsu
中科院分区：
文献类型：
--
作者：
Arase, Yasuji;Suzuki, Fumitaka;Kumada, Hiromitsu
目的：探讨丙型肝炎病毒（HCV）阳性患者特发性肺纤维化的累积发展发生率及预测因素。方法：我们研究了6150例年龄在40-70岁之间的HCV感染患者（HCV组）。另取乙型肝炎病毒（HBV）患者2050例作为对照组（HBV组）。hcv组平均观察期为8.0 +/- 5.9年，hbv组平均观察期为6.3 +/- 5.5年。主要目标是两组患者发生特发性肺纤维化（IPF）。采用Kaplan-Meier法和Cox比例风险模型计算IPF的累计出现率和与IPF发病率相关的独立因素。所有的研究都是通过收集和分析我院的病历资料进行回顾性研究的。结果：hcv组15例发生IPF。另一方面，hbv组没有患者发生IPF。在hcv组中，第10年IPF的累积发生率为0.3%，第20年为0.9%。hcv组IPF发生率高于hbv组(P = 0.021)。HCV或HBV患者IPF发生率较高，以下病例有统计学意义：(1)患者>= 55岁（P < 0.001）；(2)吸烟指数（包/天x年）>= 20的患者（P = 0.002）；③肝硬化患者（P = 0.042）。结论：年龄、吸烟和肝硬化均可促进HCV阳性患者IPF的发展。(C) 2008 WJG出版社。版权所有。
AIM: To investigate the cumulative development incidence and predictive factors for idiopathic pulmonary fibrosis in hepatitis C virus (HCV) positive patients.METHODS: We studied 6150 HCV infected patients who were between 40-70 years old (HCV-group). Another 2050 patients with hepatitis B virus (HBV) were selected as control (HBV-group). The mean observation period was 8.0 +/- 5.9 years in HCV-group and 6.3 +/- 5.5 years in HBV-group. The primary goal is the development of idiopathic pulmonary fibrosis (IPF) in both groups. The cumulative appearance rate of IPF and independent factors associated with the incidence rate of IPF were calculated using the Kaplan-Meier method and the Cox proportional hazard model. All of the studies were performed retrospectively by collecting and analyzing data from the patient records in our hospital.RESULTS: Fifteen patients in HCV-group developed IPF. On the other hand, none of the patients developed IPF in HBV-group. In HCV-group, the cumulative rates of IPF development were 0.3% at 10th year and 0.9% at 20th year. The IPF development rate in HCV-group was higher than that in HBV-group (P = 0.021). The IPF development rate in patients with HCV or HBV was high with statistical significance in the following cases: (1) patients >= 55 years (P < 0.001); (2) patients who had smoking index (package per day x year) of >= 20 (P = 0.002); (3) patients with liver cirrhosis (P = 0.042).CONCLUSION: Our results indicate that age, smoking and liver cirrhosis enhance the development of IPF in HCV positive patients. (C) 2008 The WJG Press. All rights reserved.