High incidence of myocarditis by endomyocardial biopsy in patients with idiopathic congestive cardiomyopathy.
High incidence of myocarditis by endomyocardial biopsy in patients with idiopathic congestive cardiomyopathy.
复制标题
特发性充血性心肌病患者经心内膜心肌活检发现心肌炎的发生率较高。
DOI：
10.1016/s0735-1097(84)80431-3
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发表时间：
1984
影响因子：
24
通讯作者：
George A. Williams
中科院分区：
文献类型：
--
作者：
Chi;Cheng Chang Tsai;Diane C. Palmer;J. Codd;D. Glenn Pennington;George A. Williams
35例不明原因的充血性心力衰竭患者进行了评价与肌内膜活检。利用显微镜、超微结构和免疫荧光研究，将样本分类为无炎症（心肌病）或活动性淋巴细胞性心肌炎，I至IV级。22例（63%）患者有炎症变化。在这22名患者中，18名患有I级或II级轻度炎症，7名接受免疫抑制剂治疗，其中5名改善，1名稳定。1例患者死于进行性充血性心力衰竭。4例III级或IV级心肌炎患者中有3例在暴发性病程后死亡。结果表明，炎症性心肌炎可能比以前怀疑的更常见，并增加了证据表明，在许多充血性心肌病病例中可能存在持续的炎症。
Thirty-five patients with unexplained congestive heart failure were evaluated with endomyocardial biopsy. Utilizing microscopic, ultrastructural and immunofluores-cent studies, samples were classified as exhibiting either no inflammation (cardiomyopathy) or active lymphocytic myocarditis, grade I to IV. Twenty-two (63%) of the patients had inflammatory changes. Of these 22 patients, 18 had low grade I or II inflammation, 7 were treated with immunosuppressive agents with improvement in 5 and stabilization in 1. One patient died of progressive congestive heart failure. Three of four patients with high grade III or IV myocarditis died after a fulminant course. The results suggest that inflammatory myocarditis may be more common than previously suspected and add evidence that there may be ongoing inflammation in many cases of congestive cardiomyopathy.