Canine acute leukaemia: 50 cases (1989-2014).
Canine acute leukaemia: 50 cases (1989-2014).
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DOI：
10.1111/vco.12251
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发表时间：
2017-09
影响因子：
2.1
通讯作者：
Hess PR
中科院分区：
文献类型：
--
作者：
Bennett AL;Williams LE;Ferguson MW;Hauck ML;Suter SE;Lanier CB;Hess PR
急性白血病（AL）是一种造血祖细胞的骨髓恶性肿瘤，历来对治疗反应不佳。随着剂量密集型化疗的广泛采用，更多的人类患者获得了长期生存，但犬 AL 是否取得了类似的进展尚不清楚。为了调查这个问题，我们查阅了三个学术兽医医院的医疗记录。 50 只狗符合 AL 的标准，有过多的循环或骨髓母细胞、严重的血细胞减少，并且没有明显的淋巴结肿大。三十六只狗接受了细胞毒性化疗； 23 人在中位数 56 天（范围 9 – 218）内实现完全或部分缓解。由于失败或复发，14只狗获救。治疗后的中位生存期很差，为 55 天（范围：1 – 300）。未经治疗 (n=6) 和接受姑息治疗 (n=8) 的狗的中位寿命为 7.5 天。大多数狗在开始治疗后几周内就会产生化疗耐药性，因此 AL 的存活时间仍然短得令人失望。
Acute leukemia (AL) is a bone marrow malignancy of hematopoietic progenitors that historically is poorly responsive to treatment. With the widespread adoption of dose-intense chemotherapy, more human patients attain long-term survivals, but whether comparable progress has been made in canine AL is unknown. To investigate this question, medical records from three academic veterinary hospitals were reviewed. Fifty dogs met the criteria for AL, having excess circulating or marrow blasts, a major cytopenia(s), and no substantial lymphadenopathy. Thirty-six dogs received cytotoxic chemotherapy; 23 achieved a complete or partial response for a median of 56 days (range, 9 – 218). With failure or relapse, 14 dogs were rescued. Median survival with treatment was poor at 55 days (range, 1 – 300). Untreated (n=6) and palliatively-treated (n= 8) dogs lived a median of 7.5 days. Most dogs developed chemoresistance within weeks of initiating treatment, and consequently, survival times for AL remain disappointingly short.