A role for the bacterial outer membrane in the pathogenesis of Helicobacter pylori infection
A role for the bacterial outer membrane in the pathogenesis of Helicobacter pylori infection
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DOI：
10.1111/j.1574-6968.2000.tb08905.x
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发表时间：
2000-01-15
影响因子：
2.1
通讯作者：
Bagshaw, P
中科院分区：
文献类型：
--
作者：
Keenan, J;Day, T;Bagshaw, P
人类幽门螺杆菌感染与多种临床结局相关，部分原因是细菌菌株差异。分泌的细菌产物被认为与这种非侵入性细菌引起的发病机制有关。感染个体的胃活检的电子显微镜显示幽门螺杆菌外膜起泡，类似于细菌在肉汤中生长时发生的外膜囊泡脱落过程。孔蛋白，一类促炎蛋白，观察到外膜囊泡。VacA细胞毒素由50-60%的H.幽门螺杆菌菌株，并与感染的发病机制增加，也被发现是囊泡相关的和生物活性。这支持了这样的假设，即这些囊泡代表了将破坏性细菌产物递送至胃粘膜的载体。(C)2000年，欧洲微生物学会联合会。由Elsevier Science B. V.出版，版权所有。
Helicobacter pylori infection in humans is associated with diverse of clinical outcomes which are partly attributed to bacterial strain differences. Secreted bacterial products are thought to be involved in the pathogenesis caused by this non-invasive bacterium. Electron microscopy of gastric biopsies from infected individuals revealed blebbing of the H, pylori outer membrane, similar to the process of outer membrane vesicle shedding which occurs when the bacterium is grown in broth. Porins, a class of proinflammatory proteins, were observed in the outer membrane vesicles. The VacA cytotoxin, which is produced by 50-60% of H. pylori strains and associated with increased pathogenesis of infection, was also found to be vesicle-associated and biologically active. This supports the hypothesis that these vesicles represent a vehicle for the delivery of damaging bacterial products to the gastric mucosa. (C) 2000 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.