Enhancer transcription: what, where, when, and why?
Enhancer transcription: what, where, when, and why?
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DOI：
10.1101/gad.311605.118
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发表时间：
2018-01-01
影响因子：
10.5
通讯作者：
Lis JT
中科院分区：
文献类型：
--
作者：
Tippens ND;Vihervaara A;Lis JT
Tippens等人的这一展望。讨论了Henrique等人在这一期中的两篇论文。和Mikhaylichenko等人。关于果蝇中启动子和增强子的转录性质。随着广泛的增强子转录的发现，增强子和启动子被发现比之前认为的更相似。在本期《基因与发育》杂志上，两项研究(Henrique及其同事[pp.26-41]和Mikhaylichenko及其同事[pp.42-57])揭示了果蝇中启动子和增强子的转录性质。总之，这些研究支持最近在哺乳动物细胞上的工作，该工作表明，大多数活性增强剂使用与启动子相似的因子和机制来驱动局部转录。有趣的是，增强子的转录被证明是由SPT5和P-TEFb介导的暂停-释放协调的，但暂停的半衰期更短，并且在增强子上的终止比在启动子上更快。此外，启动子的双向转录与增强子活性相关，进一步支持了调控元件沿着启动子和增强子的光谱存在的模型。我们提出了一个通用的统一模型来解释转录在增强子中可能的功能。
This Outlook by Tippens et al. discusses two papers in this issue by Henriques et al. and Mikhaylichenko et al. regarding the transcriptional nature of promoters and enhancers in Drosophila. Following the discovery of widespread enhancer transcription, enhancers and promoters have been found to be far more similar than previously thought. In this issue of Genes & Development, two studies (Henriques and colleagues [pp. 26–41] and Mikhaylichenko and colleagues [pp. 42–57]) shine new light on the transcriptional nature of promoters and enhancers in Drosophila. Together, these studies support recent work in mammalian cells that indicates that most active enhancers drive local transcription using factors and mechanisms similar to those of promoters. Intriguingly, enhancer transcription is shown to be coordinated by SPT5- and P-TEFb-mediated pause–release, but the pause half-life is shorter, and termination is more rapid at enhancers than at promoters. Moreover, bidirectional transcription from promoters is associated with enhancer activity, lending further credence to models in which regulatory elements exist along a spectrum of promoter-ness and enhancer-ness. We propose a general unified model to explain possible functions of transcription at enhancers.
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影响因子：
10.5
作者：
Henriques T;Scruggs BS;Inouye MO;Muse GW;Williams LH;Burkholder AB;Lavender CA;Fargo DC;Adelman K
通讯作者：
Adelman K
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
16.6
作者：
Vihervaara A;Mahat DB;Guertin MJ;Chu T;Danko CG;Lis JT;Sistonen L
通讯作者：
Sistonen L
影响因子：
30.8
作者：
Dao, Lan T. M.;Galindo-Albarran, Ariel O.;Spicuglia, Salvatore
通讯作者：
Spicuglia, Salvatore
DOI：
10.1126/science.aag2445
发表时间：
2016-11-11
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Fulco CP;Munschauer M;Anyoha R;Munson G;Grossman SR;Perez EM;Kane M;Cleary B;Lander ES;Engreitz JM
通讯作者：
Engreitz JM