DIET AND COLORECTAL-CANCER - A CASE-CONTROL STUDY IN GREECE
DIET AND COLORECTAL-CANCER - A CASE-CONTROL STUDY IN GREECE
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DOI：
10.1002/ijc.2910320102
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发表时间：
1983-01-01
影响因子：
6.4
通讯作者：
POLYCHRONOPOULOU, A
中科院分区：
文献类型：
--
作者：
MANOUSOS, O;DAY, NE;POLYCHRONOPOULOU, A
在希腊雅典进行了一项病例对照研究，探讨饮食对结直肠癌发病率的影响，该人群的特点是种族同质性，但饮食习惯有很大的异质性。这一系列病例包括雅典两家大型医院在16个月内连续收治的100名经组织学证实的结直肠癌患者。对照组包括在同一时间段内住在同一医院的骨科患者，按年龄和性别分别与指标病例匹配。同一采访者获得了关于大约80种食物的消费频率(每月或每周)的饮食历史。病例报告的蔬菜(特别是甜菜、菠菜、生菜和卷心菜)的消费频率大大减少，而肉类(特别是羊肉和牛肉)的消费频率明显增加。在两种极端(高蔬菜、低肉类饮食与高肉类、低蔬菜饮食)之间，似乎存在大约8的风险比，这足以(在大小和方向上)解释结直肠癌发病率的大部分国际差异。没有发现与啤酒或其他酒精饮料的显著关联，也没有注意到关于年龄、性别和解剖定位(结肠与直肠)的显著交互作用。
A case-control study probing the role of diet on the incidence of colorectal cancer was undertaken in Athens, Greece, in a population characterized by ethnic homogeneity but substantial heterogeneity with respect to dietary habits. The case series consisted of 100 consecutive patients with histologically confirmed colorectal cancer admitted to two large hospitals of Athens during a 16-mo. period; the control series consisted of orthopedic patients, admitted to the same hospitals during the same time period, individually matched to the index cases by age and sex. Dietary histories concerning the frequency of consumption (per month or per week) of about 80 food items were obtained by the same interviewer. Cases reported significantly less frequent consumption of vegetables (particularly beets, spinach, lettuce and cabbage) and, independently, significantly more frequent consumption of meat (notably lamb and beef). Between the 2 extremes (high-vegetable, low-meat diet vs. high-meat, low-vegetable diet) a risk ratio of about 8 appears to exist, sufficient (in size and direction) to explain a substantial part of the international variation in the incidence of colorectal cancer. Significant associations were not found with beer or other alcoholic beverages, and significant interactions were not noted with respect to age, sex and anatomic localization (colon vs. rectum).