Inhibition of Preadipocyte Differentiation by Germacranolides from Calea urticifolia in 3T3-L1 Cells
Inhibition of Preadipocyte Differentiation by Germacranolides from Calea urticifolia in 3T3-L1 Cells
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DOI：
10.1271/bbb.69.2470
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发表时间：
2005-01
期刊：
影响因子：
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通讯作者：
N. Matsuura;M. Yamada;Hiroto Suzuki;Naoko Hasegawa;Chihiro Kurosaka;M. Ubukata;Toŝhiyuki Tanaka;M. Iinuma
中科院分区：
文献类型：
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作者：
N. Matsuura;M. Yamada;Hiroto Suzuki;Naoko Hasegawa;Chihiro Kurosaka;M. Ubukata;Toŝhiyuki Tanaka;M. Iinuma
研究了从荨麻叶牛肝菌中分离得到的大根霉内酯对3 T3-L1细胞脂肪细胞分化的影响。这些大根霉内酯在1.25-5 μM的浓度下抑制脂肪生成。但对细胞增殖无抑制活性，对蛋白质无非特异性结合活性。这些结果表明，这些germacranolides是前脂肪细胞分化的特异性抑制剂。
The effects of germacranolides isolated from Calea urticifolia on adipocytic differentiation of 3T3-L1 cells were examined. These germacranolides inhibited adipogenesis at a concentration of 1.25–5 μM. But no inhibitory activity against cell proliferation and no nonspecific binding activity to protein were observed. These results indicate that these germacranolides are the specific inhibitors of preadipocyte differentiation.