Increased levels of vascular endothelial growth factor and interleukin-6 in the aqueous humor of diabetics with macular edema
Increased levels of vascular endothelial growth factor and interleukin-6 in the aqueous humor of diabetics with macular edema
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DOI：
10.1016/s0002-9394(01)01269-7
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发表时间：
2002-01-01
影响因子：
4.2
通讯作者：
Hori, S
中科院分区：
文献类型：
--
作者：
Funatsu, H;Yamashita, H;Hori, S
目的：探讨糖尿病性黄斑水肿与血管内皮水平的关系。设计：对照横断面研究方法：对54例糖尿病患者54只眼进行研究。VEGF和IL-6的浓度在未稀释的水样（从白内障手术过程中获得的眼睛）和血浆中进行了测量的酶联免疫吸附测定。结果：黄斑水肿患者房水中VEGF、IL-6水平与黄斑水肿程度显著相关（P = 0.628，P < 0.01），而白细胞介素-6（IL-6）水平与黄斑水肿程度显著相关（P < 0.01）。
PURPOSE: To investigate the relationship between diabetic macular edema and the levels of vascular endo. thelial growth factor VEGF) and interleukin 6 (IL-6) in aqueous humor and plasma.DESIGN: Comparative cross-sectional study.METHODS: Fifty,four eyes from 54 diabetic patients were used. The concentrations of VEGF and IL-6 in undiluted aqueous specimens (obtained from the eyes during cataract surgery) and in plasma were measured by an enzyme-linked immunosorbent assay. To assess bloods aqueous barrier function, the aqueous flare intensity was measured by a laser flare,cell meter as an estimate of the aqueous protein level.RESULTS: The aqueous levels of VEGF and IL-6 were significantly correlated with the severity of macular edema (P = 0.628, P