Effects of treadmill training on functional recovery following peripheral nerve injury in rats
Effects of treadmill training on functional recovery following peripheral nerve injury in rats
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DOI：
10.1152/jn.00946.2012
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发表时间：
2013-06-01
影响因子：
2.5
通讯作者：
English, Arthur W.
中科院分区：
文献类型：
--
作者：
Boeltz, Tiffany;Ireland, Meredith;English, Arthur W.
运动，在神经切断和修复后以适度的每日跑步机训练的形式导致轴突再生增强，但其对功能恢复的影响鲜为人知。雌性大鼠通过在水平跑步机上以缓慢速度（10 m/min）连续行走1 h/天进行锻炼，从单侧横断和坐骨神经手术修复后3天开始，并进行5天/周，持续2周。在训练的大鼠，直接的肌肉反应胫神经刺激和H反射比目鱼肌出现更早，幅度增加更迅速，随着时间的推移比未训练的大鼠。恢复的H反射的功效在训练的大鼠中比在未训练的对照中更大。在未训练的大鼠跑台运动过程中，再神经支配的胫骨前肌和比目鱼肌被共激活。在训练过的动物中，比目鱼肌的激活模式，但不是胫骨前肌，与在完整大鼠中发现的没有显著差异。在两组中，神经损伤后，后肢在水平和上下坡运动期间的总长度保持不变。这种保存是通过肢体方向的改变来实现的。在所有大鼠下坡行走时，有效地保存了肢体长度，但只有在训练大鼠在水平和上坡行走。坐骨神经切断后立即进行适度的日常运动足以促进轴突再生，恢复肌肉反射，并提高大鼠科普斜坡行走的不同生物力学要求的能力。
Exercise, in the form of moderate daily treadmill training following nerve transection and repair leads to enhanced axon regeneration, but its effect on functional recovery is less well known. Female rats were exercised by walking continuously, at a slow speed (10 m/min), for 1 h/day on a level treadmill, beginning 3 days after unilateral transection and surgical repair of the sciatic nerve, and conducted 5 days/wk for 2 wk. In Trained rats, both direct muscle responses to tibial nerve stimulation and H reflexes in soleus reappeared earlier and increased in amplitude more rapidly over time than in Untrained rats. The efficacy of the restored H reflex was greater in Trained rats than in Untrained controls. The reinnervated tibialis anterior and soleus were coactivated during treadmill locomotion in Untrained rats. In Trained animals, the pattern of activation of soleus, but not tibialis anterior, was not significantly different from that found in Intact rats. The overall length of the hindlimb during level and up- and downslope locomotion was conserved after nerve injury in both groups. This conservation was achieved by changes in limb orientation. Limb length was conserved effectively in all rats during downslope walking but only in Trained rats during level and upslope walking. Moderate daily exercise applied immediately after sciatic nerve transection is sufficient to promote axon regeneration, to restore muscle reflexes, and to improve the ability of rats to cope with different biomechanical demands of slope walking.