Nuclear envelope proteins: identification of lamin B subtypes.
Nuclear envelope proteins: identification of lamin B subtypes.
复制标题
核膜蛋白：核纤层蛋白 B 亚型的鉴定。
DOI：
10.1016/0006-291x(81)90905-0
复制
发表时间：
1981
影响因子：
3.1
通讯作者：
Cochran,DL
中科院分区：
文献类型：
--
作者：
Shelton,KR;Egle,PM;Cochran,DL
这些层蛋白是一组核膜蛋白，被认为在核外围形成了一个结构层。虽然层蛋白A的一个亚型层蛋白C在鸡细胞中相对减少，但层蛋白A、B和C在许多细胞类型中都存在。在鸡细胞中发现了Lamin B的一个亚型。这种亚型被称为层蛋白B1，比现在被称为层蛋白B2的定量主要亚型略大，酸性更强。Lamin B亚型具有非常相似的初级序列，并具有独特的拓扑结构。在哺乳动物组织中没有观察到两种Lamin B亚型，但在三种禽类组织、成熟鸡的红细胞和肝脏以及11-13日龄胚胎的红细胞中发现了Lamin B亚型。由于这些组织的代谢活性差异很大，这两种亚型似乎都是构成核蛋白。
The lamins are a group of nuclear envelope proteins thought to form a structural layer at the nuclear periphery. Lamins A, B and C occur in many cell types although lamin C, a subtype of lamin A, is relatively decreased in chicken cells. A subtype of lamin B has been found in chicken cells. This subtype, called lamin B1, is slightly larger and more acidic than the quantitatively major subtype now called lamin B2. The lamin B subtypes have very similar primary sequences and share a distinctive topology. Two lamin B subtypes have not been observed in mammalian tissues but have been found in three avian tissues, erythrocytes of mature chickens and liver and erythrocytes of 11- to 13-day-old embryos. As these tissues differ widely in metabolic activity, both subtypes appear to be constitutive nuclear proteins.