Assessing determinants of maternal blood concentrations for persistent organic pollutants and metals in the eastern and western Canadian Arctic
Assessing determinants of maternal blood concentrations for persistent organic pollutants and metals in the eastern and western Canadian Arctic
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DOI：
10.1016/j.scitotenv.2015.04.079
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发表时间：
2015-09-15
影响因子：
9.8
通讯作者：
Chan, Hing Man
中科院分区：
文献类型：
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作者：
Curren, Meredith S.;Liang, Chun Lei;Chan, Hing Man
加拿大北极地区的土著居民主要通过食用传统的野生动物食品而接触到持久性有机污染物和金属。最近的研究表明，北方的许多人体化学品水平已经下降，这可能是由于全球化学品排放减少、饮食变化和地方卫生当局减轻风险的努力。母乳喂养、产次和其他母亲特征可以进一步抵消母亲体内化学品的负担。在加拿大北方，通过对176名来自努纳武特和西北地区的母亲的血液浓度和人口统计学变量进行多元逐步线性回归分析，2005-2007年期间。一个显着的原住民群体效应，观察到建模的化学品，除了铅和镉，调整后的协变量。此外，持久性有机污染物和金属的血液浓度与年龄较大、母乳喂养月数较少、更频繁地食用传统食物或怀孕期间吸烟等至少一个协变量显著相关。镉有最高的解释方差（72.5%）从两个显着的协变量（目前的吸烟状况和奇偶性）。虽然因纽特人参与者从西北地区消费更多的传统食品一般，因纽特人参与者从沿海社区在努纳武特继续表现出较高的调整后的血液中的持久性有机污染物和金属浓度在这里检查。虽然这部分是由于海洋哺乳动物在北极东部饮食中的比例较高，但与饮食无关的其他土著群体的影响也可能导致加拿大北极人群体内化学物质负担升高。皇冠版权所有（C）2015由Elsevier B. V.出版。保留所有权利。
Aboriginal peoples in the Canadian Arctic are exposed to persistent organic pollutants (POPs) and metals mainly through their consumption of a traditional diet of wildlife items. Recent studies indicate that many human chemical levels have decreased in the north, likely due to a combination of reduced global chemical emissions, dietary shifts, and risk mitigation efforts by local health authorities. Body burdens for chemicals in mothers can be further offset by breast feeding, parity, and other maternal characteristics.We have assessed the impact of several dietary and maternal covariates following a decade of awareness of the contaminant issue in northern Canada, by performing multiple stepwise linear regression analyses from blood concentrations and demographic variables for 176 mothers recruited from Nunavut and the Northwest Territories during the period 2005-2007. A significant aboriginal group effect was observed for the modeled chemicals, except for lead and cadmium, after adjusting for covariates. Further, blood concentrations for POPs and metals were significantly associated with at least one covariate of older age, fewer months spent breastfeeding, more frequent eating of traditional foods, or smoking during pregnancy. Cadmium had the highest explained variance (72.5%) from just two significant covariates (current smoking status and parity).Although Inuit participants from the Northwest Territories consumed more traditional foods in general, Inuit participants from coastal communities in Nunavut continued to demonstrate higher adjusted blood concentrations for POPs and metals examined here. While this is due in part to a higher prevalence of marine mammals in the eastern Arctic diet, it is possible that other aboriginal group effects unrelated to diet may also contribute to elevated chemical body burdens in Canadian Arctic populations. Crown Copyright (C) 2015 Published by Elsevier B.V. All rights reserved.